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alkaline phosphatase/betændelse
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[Diagnostic significance of determining gamma-glutamyltranspeptidase and alkaline phosphatase activity in blood serum and bile in viral hepatitis B and in bile duct inflammation].
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Diagnostic importance of gamma-glutamyl transpeptidase and alkaline phosphatase activities estimation in bile was demonstrated during inflammation of biliary ducts and gallbladder. Activation of these enzymes in B-bile in cholecystitis and in B- and C-bile--in cholecystocholangitis enabled to
Effects of a human recombinant alkaline phosphatase on renal hemodynamics, oxygenation and inflammation in two models of acute kidney injury.
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Two small clinical trials indicated that administration of bovine intestinal alkaline phosphatase (AP) improves renal function in critically ill patients with sepsis-associated acute kidney injury (AKI), for which the mechanism of action is not completely understood. Here, we investigated the
Alternative therapy in prevention of experimental and clinical inflammatory bowel disease. Impact of regular physical activity, intestinal alkaline phosphatase and herbal products.
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Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are multifactorial, chronic, disabling, and progressive diseases characterised by cyclical nature, alternating between active and quiescent states. While the aetiology of IBD is not fully understood, this complex of
Bovine Intestinal Alkaline Phosphatase Reduces Inflammation After Induction of Acute Myocardial Infarction in Mice.
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BACKGROUND
There has been increasing evidence suggesting that lipopolysaccharide or endotoxin may be an important activator of the innate immune system after acute myocardial infarction. Bovine intestinal alkaline phosphatase reduces inflammation in several endotoxin mediated diseases by
Influence of non-steroidal anti-inflammatory drugs and disease activity on serum alkaline phosphatase concentrations in rheumatoid arthritis, osteoarthritis, and polymyalgia rheumatica.
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The influence of non-steroidal anti-inflammatory drugs (NSAIDs) and of disease activity on the serum alkaline phosphatase concentration was examined in patients with rheumatoid arthritis, osteoarthritis, and polymyalgia rheumatica. Concentrations of serum alkaline phosphatase were similar both in
The decrease of IGF-I, IGF-binding protein-3 and bone alkaline phosphatase isoforms during gluten challenge correlates with small intestinal inflammation in children with coeliac disease.
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OBJECTIVE
In children with coeliac disease, the ingestion of gluten causes small intestinal inflammation and a clinical picture of malabsorption, weight reduction and short stature. Decreased alkaline phosphatase (ALP) during gluten challenge was found in a previous study. ALP is a marker of bone
[The role of intestinal alkaline phosphatase in pediatric inflammatory bowel and celiac diseases].
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Intestinal alkaline phosphatase enzyme plays a pivotal role in the maintenance of intestinal mucosal barrier integrity with the detoxification capacity of lipopolysaccharide, the ligand of Toll-like receptor 4. The inappropriate immune responses and the damage of the mucosal barrier may contribute
[Alkaline phosphatase of the bile as a criterion of biliary tract inflammation].
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Estimation of alkaline phosphatase activity is a sensitive and specific test for biliary tract inflammation. The enzyme penetrates into bile from biliary tract epithelium. Activation of the enzyme was noted in cholelithiasis, while the maximal level of alkaline phosphatase activity was detected in
Studies on the time course of dithranol-induced inflammation by quantification of alkaline phosphatase.
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An inflammatory response of the skin to dithranol-induced free radicals seems to be essential for its clinical efficacy. In normal volunteers this response was evaluated at the level of the microvasculature following 30 min, 2 h and 24 h applications, using a functional parameter (erythema) and a
[Alkaline phosphatase in mixed saliva in abdominal inflammatory diseases and gestoses].
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By applying enzyme electrophoresis in the agar gel prepared on veronal-medinal buffer (pH 8.6) (the substrate was naphthol AS phosphate; the dye was fast blue B or PP), the authors first revealed mixed salivary alkaline phosphatase (AP) that differed in physicochemical properties from the known
Gingival crevicular fluid alkaline phosphatase activity reflects periodontal healing/recurrent inflammation phases in chronic periodontitis patients.
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BACKGROUND
Roles for host enzymes as diagnostic indicators of periodontal status in gingival crevicular fluid (GCF) have been proposed. One of these host enzymes is alkaline phosphatase (ALP), the GCF activity of which has been associated with periodontal inflammation. Thus, the present study aimed
Intestinal alkaline phosphatase administration in newborns decreases systemic inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model.
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BACKGROUND
Supplementation of intestinal alkaline phosphatase (IAP), an endogenous protein expressed in the intestines, decreases the severity of necrotizing enterocolitis (NEC)-associated intestinal injury and permeability. We hypothesized that IAP administration is protective in a dose-dependent
Serum alkaline phosphatase activity during zinc deficiency and long-term inflammatory stress.
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A decrease in serum zinc can be caused by a real zinc deficiency but can also be caused by an apparent zinc deficiency, e.g. in inflammatory stress. The aim of this study was to evaluate the diagnostic power of serum alkaline phosphatase (AP) activity in the discrimination between pathophysiologic
Bovine intestinal alkaline phosphatase attenuates the inflammatory response in secondary peritonitis in mice.
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Lipopolysaccharide (LPS) contributes importantly to morbidity and mortality in sepsis. Bovine intestinal alkaline phosphatase (BIAP) was demonstrated to detoxify LPS through dephosphorylation. LPS injection combined with BIAP reduced inflammation and improved survival in various experimental
Loss of attachment in the marginal periodontium of the rat incisor under non-inflammatory conditions. Expression of alkaline phosphatase activity. Experimental Oral Biology Group.
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Alkaline phosphatase (ALP) has been suggested to play a role in acellular cementum formation and maintenance of periodontal attachment. In an attempt to determine whether changes in attachment level are associated with altered expression of ALP-activity in the periodontium we induced natural loss of
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