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alkaline phosphatase/kræft
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Alkaline phosphatase compositions to reduce skin cancer
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FIELD OF THE INVENTION
This invention relates to the use of human alkaline phosphatase, such as placental alkaline phosphatase or transferrin alone or alkaline phosphatase in combination with transferrin, and, optionally, .alpha..sub.1-antitrypsin to prevent or reduce the growth of skin cancer in
Use of alkaline phosphatase to maintain healthy tissue mass in mammals
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FIELD OF THE INVENTION
Embodiments of this invention relate to the use of an alkaline phosphatase, such as placental alkaline phosphatase ("PALP"), to maintain muscle and adipose tissue mass in aging or diseased humans, who may or may not be treated with weight loss-inducing therapies. Alkaline
Use of alkaline phosphatase to maintain healthy tissue mass in mammals
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FIELD OF INVENTION
Embodiments of this invention relate to the use of an alkaline phosphatase, such as placental alkaline phosphatase ("PALP"), to maintain muscle and adipose tissue mass in aging or diseased humans, who may or may not be treated with weight loss-inducing therapies. Alkaline
Electrochemical methods of detecting cancer with 4-aminophenyl phosphate
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FIELD AND BACKGROUND OF THE INVENTION
The present invention relates to a method of detecting cancer and, more particularly, to methods of optimizing drug treatment for cancer.
Cancer is responsible for the majority of morbidity and mortality worldwide, despite recent advances in medical technology.
Tumor-specific minicircles for cancer screening
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SEQUENCE LISTING
The present disclosure includes a sequence listing incorporated herein by reference in its entirety.
FIELD OF THE DISCLOSURE
The present disclosure relates to recombinant nucleic acid minicircles useful for the tumor-specific expression of heterologous coding nucleic acid sequences
Compounds useful as alkaline phosphatase inhibitors and therapeutic agents
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FIELD OF THE INVENTION
This invention relates generally to novel compounds useful as inhibitors of alkaline phosphatase. These compounds are useful in immunoassays. They can be used as cancer therapeutics; antihelmintics; anti-depressive/psychoenergising, antianergic, and anti-anorexigenic
Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
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TECHNICAL FIELD OF THE INVENTION
The present invention relates to a novel method for the delivery of cytotoxic agents to tumor cells by the combined use of antibody-enzyme conjugates and prodrugs. More particularly, this invention relates to a method for the delivery of cytotoxic drugs to the site
Placental like alkaline phosphatase (PLAP) promoter mediated cell targeting
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FIELD OF INVENTION
The present invention relates to cell specific therapeutic modality by using a region of the PLAP Promoter. The invention further relates to specific expression of therapeutically useful sequences for specific transcriptional activation under PLAP promoter. The invention also
Substituted 1,2,3,4-tetrahydroisoquinoline derivatives for the treatment of hormone-dependent diseases
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FIELD OF THE INVENTION
The invention relates generally to compounds for the treatment of medical conditions involving hormones. More specifically, the invention relates to compounds, their preparation and their use in the treatment of hormone-dependent diseases including hormone-dependent cancers. A
Nucleic acid molecules encoding human 4-1BB
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FIELD OF THE PRESENT INVENTION
The present invention relates to a previously unknown human receptor protein, H4-1BB, which was isolated and identified based upon work with a homologous murine (mouse) receptor protein, 4-1BB, which was isolated and identified by specific expression of the T cell
Method of using human receptor protein 4-1BB
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The subject matter described herein was in part a subject invention of NIH Grants Nos. IR23AI23058-03, R01 AI-28175, R01 DE-12156, and P60 KD20542 of which the present inventor was the Principal Investigator and either the Donald Guthrie Foundation for Medical Research Inc. of Guthrie Square, Sayre,
Antibody specific for H4-1BB
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FIELD OF THE PRESENT INVENTION
The present invention relates to the therapeutic and scientific uses for the human H4-1BB protein, its ligands, and the development of monoclonal antibodies that recognize and bind the H4-1BB receptor protein.
BACKGROUND OF THE PRESENT INVENTION
The immune system of
Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals using carprofen and derivatives
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The present invention relates to the use of carprofen in mammals as a means of treating and preventing cartilage and subchondral bone injury and loss in the inflamed joints of such mammals. Such damage to the cartilage and subchondral bone is a natural sequelae of the process of osteoarthritis and
Purified limonin glucoside for prevention and treatment of chronic diseases
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FIELD OF THE INVENTION
The present invention relates to the use of purified limonoin glucoside for the treatment of chronic inflammatory diseases.
BACKGROUND OF THE INVENTION
Circulating concentrations of the hepatic enzymes gamma glutamyl transferase (GGT), alanine amino transferase (ALT), alkaline
Detection of antibodies against a chorionic gonadotropin-like substance
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FIELD OF THE INVENTION
The present invention relates generally to immunological testing methods, and more particularly to such methods for detection of antibodies against a chorionic gonadotropin-like substance.
SUMMARY OF THE INVENTION
The present invention comprises a method of detecting the
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