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Intronic mutations affecting splicing of MBTPS2 cause ichthyosis follicularis, alopecia and photophobia (IFAP) syndrome.
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Ichthyosis follicularis, alopecia and photophobia (IFAP) syndrome is an X-linked genodermatosis with congenital atrichia being the most prominent feature. Recently, we have shown that functional deficiency of MBTPS2 (membrane-bound transcription factor protease site 2) - a zinc metalloprotease
The mRNA for protease nexin-1 is expressed in human dermal papilla cells and its level is affected by androgen.
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Protease nexin-1, an inhibitor of serine proteases, plays important parts in the regulation of the growth, differentiation, and death of cells by modulating proteolytic activity. The mRNA for protease nexin-1 accumulates in rat dermal papilla cells in a hair cycle-dependent fashion and its levels
The role of plasminogen activators in alopecia areata.
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Plasminogen activators are serine proteinases which transform the serum zymogen, plasminogen, into plasmin, a broad-spectrum protease with fibrinolytic effect. Two main plasminogen activators have been described in humans: urokinase (UK; molecular weight, 55,000) and tissue-type plasminogen
Ichthyosis Follicularis, Alopecia, and Photophobia Syndrome.
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Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome is a rare genetic, oculocutaneous disorder. So far, about forty patients have been reported worldwide. This disorder results from mutations in the membrane-bound transcription factor protease site 2 gene that impairs cholesterol
The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles.
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Mice lacking the ubiquitously expressed lysosomal cysteine protease cathepsin L, show a complex skin phenotype consisting of periodic hair loss and epidermal hyperplasia with hyperproliferation of basal epidermal keratinocytes, acanthosis and hyperkeratosis. The recently identified human cathepsin
Mapping of the genes for tubular basement membrane antigen and a submaxillary gland protease in the rat.
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The gene for tubular basement membrane (Tbm) antigen in the rat has been mapped relative to other markers in the first linkage group, and a polymorphic locus for a submaxillary gland protease, Tamase-1, has been identified. The hair-loss mutation fuzzy has also been mapped and occupies a position
Antiretroviral-Related Alopecia in HIV-Infected Patients.
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Objective: To review the literature evaluating antiretroviral-related alopecia and to provide guidance on the differential diagnosis and management of this condition.
METHODS
A literature search was performed using PubMed, MEDLINE, Embase, International Pharmaceutical Abstracts (IPA), Cumulative
Indinavir use: associated reversible hair loss and mood disturbance.
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We present the case of a 55-year-old heterosexual man who had a generalized alopecia and mood changes associated with the antiretroviral protease inhibitor; indinavir within 6 months of use. This was reversed within 3 months of change of therapy to the protease inhibitor, nelfinavir with
Growth inhibition of mouse skin tumor by serine protease inhibitor ONO-3403.
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The new serine protease inhibitor, ONO-3403 is an analog of FOY-305 (Foypan). The IC50s values of ONO-3403 toward serine proteases, such as trypsin, plasmin, kallikrein and thrombin are much lower than that of FOY-305. To investigate the growth-suppressing effect of ONO-3403 on
Hair loss induced by lopinavir-ritonavir.
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A 38-year-old Caucasian woman with uncontrolled human immunodeficiency virus (HIV) infection was treated with highly active antiretroviral therapy (HAART) consisting of zidovudine, lamivudine, and nevirapine. Because her therapeutic response was inadequate, the HAART regimen was changed to abacavir,
Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity.
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The paracaspase Malt1 is a key molecule in mediating Ag receptor-induced NF-κB activation in lymphocytes, but the role of Malt1 in the function of regulatory T (Treg) cells is still unclear. In this article, we reported that specific deletion of Malt1 in Treg cells would lead to Scurfy-like
Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch.
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BACKGROUND
Patients with central centrifugal cicatricial alopecia (CCCA) often suffer from varying degrees of itch, pain and burning sensations. However, the neural component of these skin sensations has not been assessed.
OBJECTIVE
To conduct a comprehensive analysis of C nerve fibre function
Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis.
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Proteolytic events at the cell surface are essential in the regulation of signal transduction pathways. During the past years, the family of type II transmembrane serine proteases (TTSPs) has acquired an increasing relevance because of their privileged localization at the cell surface, although our
Androgenetic Alopecia Present in the Majority of Hospitalized COVID-19 Patients - The "Gabrin Sign"
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Keywords: 5-alpha reductase; COVID-19; Dutasteride; Enzalutamide; Finasteride; SARS-CoV-2; Spironolactone; TMPRSS2; androgen receptor; androgenetic alopecia; anti-androgen therapy; human skin; transmembrane protease serine 2.
Cell type-specific functions of the lysosomal protease cathepsin L in the heart.
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Deficiency of the lysosomal cysteine protease cathepsin L (Ctsl) in mice results in a phenotype affecting multiple tissues, including thymus, epidermis, and hair follicles, and in the heart develops as a progressive dilated cardiomyopathy (DCM). To understand the role of Ctsl in the maintenance of
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