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amide/betændelse
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Method of treating ocular inflammatory and angiogenesis-related disorders of the posterior segment of the eye using an amide derivative of flurbiprofen or ketorolac
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FIELD OF THE INVENTION
This invention relates to the treatment of ophthalmic disorders. In particular, this invention relates to the topical use of certain amide derivatives of flurbiprofen or ketorolac to treat or prevent ophthalmic inflammatory and angiogenesis-related disorders of the posterior
Amide therapeutics and methods for treating inflammatory bowel disease
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to the treatment of inflammatory bowel disease (IBD). More specifically, this invention is directed to methods for treating or preventing IBD using amide compounds. This invention is also directed to pharmaceutical
Amide therapeutics for the treatment of inflammatory bowel disease
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to the treatment of inflammatory bowel disease (IBD). More specifically, this invention is directed to methods for treating or preventing IBD using amide compounds. This invention is also directed to pharmaceutical
Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis
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BACKGROUND OF THE INVENTION
The present invention is directed to methods of treating vascular inflammatory pathologies such as atheroslcerosis and stroke. In particular, the invention is directed to the use of certain compounds having potent anti-inflammatory and anti-oxidant activity.
Free radical
Azabicycloalkyl and azatricycloalkyl amides used to treat inflammation, allergy, asthma and skin disorders
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BACKGROUND OF THE INVENTION
A. Field of the Invention
The present invention relates to novel hindered amides and more particularly relates to multicycloalkyl and azamulticycloalkyl amides which are 5-lipoxygenase inhibitors and are useful as anti-inflammatory and anti-allergy agents.
It is well
Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio amides used to treat inflammation, allergy, asthma and skin disorders
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to novel hindered amides and more particularly relates to multicycloalkyl and azamulticycloalkyl amides which are 5-lipoxygenase inhibitors and are useful as anti-inflammatory and anti-allergy agents.
It is well
Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides
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BACKGROUND OF THE INVENTION
A. Field of the Invention
The present invention relates to novel heterocyclic amides and more particularly relates to heterocyclic amides which are 5-lipoxygenase inhibitors and are useful as anti-inflammatory and anti-allergy agents.
It is well recognized that
Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory products
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BACKGROUND OF THE INVENTION
The present invention is directed to the provision of compounds having potent anti-inflammatory and anti-oxidant activity. The invention is further directed to compositions containing the compounds of the present invention for use in pharmaceutical applications. The
Amide, sulfonamide, urea, carbamate, thiocarbamate, and thiourea derivatives of 4'hydroxybenzylamine having anti-inflammatory and analgesic activity
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BACKGROUND OF THE PRESENT INVENTION
The present invention is novel compounds, which are derivatives of hydroxybenzylamine and as such are related to capsaicin. The present compounds have antiinflammatory activity for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel
4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity
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STATE OF THE ART
U.S. Pat. No. 4,486,438 describes racemic 4-hydroxy-2-(1-hydroxypropyl)-N-(2-thiazolyl)-8-trifluoromethyl-3-quinolin e-carboxamide as having analgesic activity.
OBJECTS OF THE INVENTION
It is an object of the invention to provide the novel compounds of formula I and their salts with
Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs
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BACKGROUND OF THE INVENTION
The present invention is directed to the provision of compounds having potent anti-inflammatory and anti-oxidant activity. The invention is further directed to compositions containing the compounds of the present invention for use in pharmaceutical applications. The
Di-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega alkanedioates and N,N-bis-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega-dialkanoic acid amides as anti-inflammatory agents
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is directed to novel substituted di-[5-hydroxy-2(5H)-4-furanonyl]alkylmethyl- alkane-dioates and N,N-bis-[5-hydroxy-2(5H)-4-furanonyl]alkylmethyl- dialkanoic acid amides which are active as anti-inflammatory agents. The
Di-(5-hydroxy-2(5H)-2-oxo-4-furyl)methyl-alpha,omega alkane-dioates and N,N-bis-(5-hydroxy-2(5H)-2-oxo-4-furyl)methyl-alpha,omega-dialkanoic acid amides as anti-inflammatory agents
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is directed to novel substituted di-[5-hydroxy-2(5H)-4-furanonyl]methyl- alkane-dioates and N,N-bis-[5-hydroxy-2(5H)-4-furanonyl]methyl- dialkanoic acid amides which are active as anti-inflammatory agents. The present
Method and compounds for reducing dermal inflammations
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to the treatment of indolent dermal irritations. More specifically, it concerns treatment of persistent inflammations such as chemical ulcers, herpes ulcers, radiation burns, psoriasis and sunburn.
2. General Background of
Method for detecting and locating inflammatory or tumor foci in a patient and diagnostic kit therefor
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The present invention relates to aerosol compositions containing a carrier agent capable agent capable of recognizing and binding to inflammatory and tumor foci mobilizing macrophages in their immediate environment, and an aerosol substrate.
More especially, the present invention relates to aerosol
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