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The Role of Concomitant Diseases in Postoperative Complications Risk Stratification.

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Advances in modern anesthesiology have significantly reduced the risk of anesthesia compared to the last century, however, the level of perioperative hospital mortality of planned operations at the moment is on average about 0.5% (ISOS group, 2016). Weiser et al. (2016) estimated that more than 313

Endogenous Melatonin Level and Pre- Postoperative Anxiety in Bariatric Surgery Patients.

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Bariatric surgical procedures, including gastric bypass, vertical sleeve gastrectomy, and biliopancreatic diversion, are the most effective and durable treatments for obesity. Bariatric surgery provides long-term benefit for patients with diabetes, fatty liver disease, and other metabolic disorders,

Topiramate and Schizophrenia: Effects on Weight and Psychopathology

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Schizophrenia is a chronic illness characterized by social and vocational disruptive functioning. While >70% of individuals with first episode illness respond to antipsychotics (APs), there remains a subgroup left with persisting psychotic symptoms. For these individuals, clozapine (CLZ) is also the

Vortioxetine for Binge Eating Disorder

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Binge-eating disorder recently included in the Diagnostic and Statistical Manual, 5th Edition, is now recognized as a serious public health problem. Binge-eating disorder is associated with obesity and psychiatric comorbidities, including depression, and may be predictive of metabolic syndrome. Many

Determination of Vitamin D Dose to Maintain Sufficiency Amongst Indian and Malay Women in the Tropics

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This randomized controlled trial will evaluate the appropriate dose of Vitamin D required to maintain Vitamin D sufficiency amongst Indian and Malay PMO women. The study will last for six months. 150 PMO women of Indian and Malay ethnicity will be randomly allocated into 3 different dosing regimens

Predictive Factors for LBP Interventional Treatment Outcomes

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This will be an observational study with a 3-month follow-up. The course of clinical treatment will be decided by a physician independent of the research. Besides filling out questionnaires and standardized follow-up visits, all subjects will receive the same care they would if they did not

Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder

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Obesity has been declared the number one illness of the 21st Century in industrialized countries, and is reaching epidemic proportions. Adoption, twin and family studies have reported that obesity has a strong heritable component and in particular, it has been suggested that BMI in adults is due to

Gabapentin for Prophylaxis Intrathecal Morphine-Induced Pruritus

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The study was approved by the ethic committee of Songklanagarind Hospital in Songkhla, Thailand, and was designed as a randomized, double-blind, placebo-controlled trial. All patients gave their informed consent after receiving written information of the study. Orthopedic patients were invited to

The Role of Vitamin D in Menopause: Relationship to Menopausal Symptoms in Body Composition

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It is increasingly recognized that Vitamin D deficiency affects more than just bone health. Links between Vitamin D deficiency have been established or purported for diabetes, the metabolic syndrome, cardiovascular disease, and cancer. We propose to explore if Vitamin D replacement (safe, readily

Aminophylline and Cognitive Function After Sevoflurane Anaesthesia

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One-hundred-eighty ASA I-II patients aged 18-55 years scheduled for elective ambulatory general surgery with a duration >1 h under general anaesthesia were enrolled in this double-blinded placebo-controlled randomised study after obtaining of the approval of Institutional Ethical Committee of

Effects of Divalproex Sodium on Food Intake, Energy Expenditure, and Posture Allocation

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Depakote (Abbott Laboratories, Abbott Park, IL) is an anti-convulsant medication used to treat epilepsy [1] and mania associated with bipolar disorder [2, 3]. Depakote also is used as a prophylaxis for migraine headache [4]. One side effect of Depakote that negatively influences its appeal to health

Lamotrigine and Oral Contraceptives

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Lamotrigine is widely used as an antiepileptic drug in the treatment of newly onset as well as refractory epilepsy (1;2). Lamotrigine is unique among the antiepileptic drug since the major route (76%) of elimination is conjugation with glucuronic acid (glucuronidation) (3). This conjugation reaction

Efficacy of Topiramate for Weight Loss in Subjects With Metabolic Syndrome

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Topiramate is an anti-convulsant which has been approved for use as adjunctive treatment for partial-onset seizures, Lennox-Gastaut syndrome, or primary generalized tonic-clonic seizures. Topiramate is currently under investigation for other disorders including binge-eating disorder. Metabolic

Zonegran in the Treatment of Binge Eating Disorder Associated With Obesity

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Binge eating disorder (BED) is characterized by recurrent, uncontrollable, and distressing episodes of excessive food consumption (binge eating) without compensatory weight loss behaviors.1,2 Its prevalence in the general population of the United States is conservatively estimated to be 1.5% to

Efficacy and Safety Study of Topiramate to Treat Restless Legs Syndrome

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Benzodiazepines, levo-dopa/carbidopa, dopamine agonists, anticonvulsants, and opioids have been used with variable success, to treat RLS. Often, RLS patients treated with a benzodiazepine, over the course of several months, develop tolerance to the medication. Also, benzodiazepines can cause

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