A topical composition for anti-aging treatment of the skin includes water soluble extract of Uncaria species, Arabidopsis thaliana extract, lipoic acid, dimethylethanolamine, tetrahexyldecyl ascorbate, dimethyl sulfoxide, Glycyrrhiza Glabra(Licorice) root extract, methylsulfonylmethane, phytosterols, D-ribose, tocotrienol, tocopherol, glucosamine hydrochloride, Pisum sativum extract; Bambusa vulgaris extract, and a dermatologically acceptable liposomal delivery medium. Further disclosed is a method using the topical composition for anti-aging skin treatment utilizing DNA repair in both the nucleus and the mitochondria. The topical composition can be applied on the skin of a person daily, and can also be applied in a dermal infusion treatment, with or without micro-dermal abrasion or skin suction. Topical application of the composition achieves effective reduction of pigmentation spots and degree of winkles, and improvement of skin color tone.

Giampapa; Vincent C.

Cellhealth Technologies Ltd.

Topical composition for anti-aging skin treatment using dual DNA repair mechanism and method of use

The present invention provides a recombinant DNA molecule encoding a fusion protein, comprising a first DNA sequence encoding a high-efficiency transit peptide operably linked to a second DNA sequence encoding a passenger protein, wherein the high-efficiency transit peptide is selected from the group consisting of transit peptides of the precursors of translocon at the inner envelope membrane of chloroplasts 40 kD (prTic40), chaperonin 10-2 (prCpn10-2), Fibrillin 1B (prFibrillin), ATP sulfurylase 1 (prAPS1), ATP sulfurylase 3 (prAPS3), 5'-adenylylsulfate reductase 3 (prAPR3), stromal ascorbate peroxidase (prsAPX), prTic40-E2A (a prTic40 variant), prCpn10-1-.DELTA.C7C37S (a chaperonin 10-1 variant), a functional fragment of any of the transit peptides and an equivalent thereof. And the present invention also provides a method of high efficiency delivery of a protein into plastids using the high-efficiency transit peptides.

ACADEMIA SINICA

Transit peptide from Arabidopsis chloroplast ATP sulfurylase 1 and methods of use

Transit peptide from Arabidopsis chloroplast chaperonin 10-2 and methods of use

A topical composition for anti-aging and anti-UV damage treatment of the skin includes water soluble extract of Uncaria species, Arabidopsis thaliana extract, alpha lipoic acid, dimethylethanolamine, tetrahexyldecyl ascorbate, dimethyl sulfoxide, Glycyrrhiza Glabra (licorice) root extract, methylsulfonylmethane, phytosterols, D-ribose, tocotrienol, tocopherol, glucosamine hydrochloride, Pisum sativum extract; silicates of sodium, magnesium and aluminum, and a dermatologically acceptable liposomal delivery medium. The composition is useful in a method using it for anti-aging skin treatment effecting DNA repair in both the nucleus and the mitochondria. The topical composition can be applied on the skin of a person daily, and can also be applied in a dermal infusion treatment, with or without micro-dermal abrasion or skin suction. Topical application of the composition achieves effective reduction of pigmentation spots, degree of winkles, and improvement of skin color, tone and turgidity, particularly of the eyelid and facial areas.

Giampapa; Vincent C

Serrault; Kellie

Serrault; Gregory

Topical composition for skin treatment to reduce lines and wrinkles of the face and body using a dual DNA repair mechanism to address damage caused by aging and ultra-violet induced damage to the skin with combination of skin turgor enhancement compounds

ascorbate

gåsemad

arabidopsis

ascorbate/gåsemad

Topical composition for anti-aging skin treatment using dual DNA repair mechanism and method of use

Transit peptide from Arabidopsis chloroplast ATP sulfurylase 1 and methods of use

Transit peptide from Arabidopsis chloroplast chaperonin 10-2 and methods of use

Topical composition for skin treatment to reduce lines and wrinkles of the face and body using a dual DNA repair mechanism to address damage caused by aging and ultra-violet induced damage to the skin with combination of skin turgor enhancement compounds

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