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Differential effects of direct antagonism of AII compared to ACE inhibitors on serum potassium levels and azotemia in patients with severe congestive heart failure.
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OBJECTIVES. The present study was undertaken to determine if direct blockade of angiotensin II receptors by losartan potassium as compared to ACE inhibition might result in greater tolerability in patients with congestive heart failure in whom ACE inhibition resulted in hyperkalemia and azotemia.
Drug-induced life-threatening potassium disturbances detected by a pharmacovigilance program from laboratory signals.
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OBJECTIVE
Detection and reporting of drug-induced life-threatening potassium disturbances and the study of associated factors under a Pharmacovigilance Program using Laboratory Signals at a Hospital (PPLSH) during a 2-year period.
METHODS
All serum potassium levels <2 mmol/l or >7 mmol/l detected at
Azotemia in cattle.
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Blood biochemical studies were performed on 21 azotemic cattle with various disease conditions. The cattle were greater than or equal to 4 months old. Blood urea nitrogen concentrations ranged from 41 to 346 mg/dl. The azotemia was determined to be of prerenal origin in 10 cattle and of renal or
Vanadate-Induced Renal cAMP and Malondialdehyde Accumulation Suppresses Alpha 1 Sodium Potassium Adenosine Triphosphatase Protein Levels.
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It has been demonstrated that vanadate causes nephrotoxicity. Vanadate inhibits renal sodium potassium adenosine triphosphatase (Na, K-ATPase) activity and this is more pronounced in injured renal tissues. Cardiac cyclic adenosine monophosphate (cAMP) is enhanced by vanadate, while increased cAMP
Reduced incidence of hyperkalemia and azotemia in patients receiving sulindac compared with indomethacin.
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The incidence and severity of hyperkalemia and azotemia was investigated in a prospective randomized study involving 74 patients receiving either sulindac 200 mg p.o. b.i.d. or indomethacin 25 mg p.o. t.i.d. and 100 mg p.r. The mean +/- SE posttreatment increment in serum potassium was 0.8 +/- 0.1
Hyperkalemia with cardiac arrhythmia. Induction by salt substitutes, spironolactone, and azotemia.
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In two patients, severe hyperkalemia and serious cardiac arrhythmia developed after excessive use of potassium-containing salt substitutes. Both had impaired ability to handle and excrete additional potassium load due to chronic congestive heart failure, azotemia, and administration of
Hyperaldosteronism and its association with hypotension and azotaemia in canine babesiosis.
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BACKGROUND
The previous work on canine babesiosis revealed hypokalaemia and increased fractional excretion of potassium in infected dogs suggesting a role for aldosterone in the loss of potassium via the kidneys in affected dogs. Moreover, hypotension, which is one of the complications of canine
Indomethacin-induced azotaemia and hyperkalaemia: a case study.
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We present a patient in whom indomethacin treatment for acute gouty arthritis induced reversible azotaemia and hyperkalaemia. Re-introduction of the drug under controlled conditions of metabolic balance resulted in recurrence of hyperkalaemia and azotaemia, and was associated with a fall in plasma
Piretanide, a potent diuretic with potassium-sparing properties, for the treatment of congestive heart failure.
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The diuretic and clinical efficacy and safety of piretanide, a new high-ceiling loop diuretic, was determined in patients with mild to moderately severe congestive heart failure. Piretanide (n = 20) administered orally in a daily dosage of up to 24 mg was compared with placebo (n = 18) for 28 days,
Novel multivalent effects of pyrazinoylguanidine in patients with azotemia.
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In patients with azotemia, urea excretion, urea clearance, and urea/creatinine clearance ratio were increased by pyrazinoylguanidine in a dose-related manner. Urine volume and excretion of sodium greater than chloride greater than potassium tended to increase during administration of
Pre-renal azotaemia in a pony with an oesophageal obstruction.
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A case of pre-renal azotaemia is described in a 12 year old pony resulting from oesophageal obstruction of 8 days duration. Blood urea nitrogen, creatinine, calcium, inorganic phosphate, sodium, potassium, chloride and bicarbonate concentrations were monitored throughout the recovery period. After
Nonsteroidal anti-inflammatory drug-associated azotemia in the very old.
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We conducted a prospective study in 114 elderly patients to determine the renal effects of short-term therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) in the very old. Study subjects were patients in a long-term care facility (mean age, 87 years) newly begun on a regimen of NSAID therapy.
Retrospective evaluation of presenting temperature of urethral obstructed male cats and the association with severity of azotemia and length of hospitalization: 243 cats (2006-2009).
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OBJECTIVE
To evaluate whether the presenting rectal temperature and level of azotemia predicts the length of hospitalization (LOH) in a population of obstructed male cats. To describe the relationships between physical examination parameters, blood electrolytes, and azotemia in a clinical population
Let Them Eat Healthy: Can Emerging Potassium Binders Help Overcome Dietary Potassium Restrictions in Chronic Kidney Disease?
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Potassium-rich foods might provide many health benefits even to people who have declining renal function. The barrier to obtaining these health benefits has long been the concern over hyperkalemia. There are new and novel treatment options available which may enable patients with chronic kidney
Hematology of experimental acute Sarcocystis bovicanis infection in calves. II. Serum biochemistry and hemostasis studies.
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Of four Holstein-Friesian calves infected with 200,000 sporocysts of Sarcocystis bovicanis, three become ill and died on days 35, 55, and 59 of a 63-day experiment. No control calves became ill or died. Serum biochemicals and hematologic indicators of hemostasis from both groups were measured
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