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beta carboline/ødem
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3 resultater
Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat.
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We have synthesized a series of new β-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that β-carboline
The Transdermal Performance, Pharmacokinetics and Anti-inflammatory Pharmacodynamics Evaluation of Harmine-loaded Ethosomes.
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Harmine is a β-carboline alkaloid with anti-inflammatory and antipruritic effect. However, the low bioavailability and side effects of harmine severely limited its clinical application. The main objective of this study was to develop harmine-loaded ethosomes (HLE) drug delivery system for topical
Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury.
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Traumatic brain injury (TBI) is a leading cause of mortality in young individuals, and results in motor and cognitive deficiency. Excitotoxicity is an important process during neuronal cell death, which is caused by excessive release of glutamate following TBI. Astrocytic glutamate transporters have
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