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beta glucuronidase/hypoxia
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[Changes in beta-glucuronidase activity in arterial and jugular vein blood, and in cerebrospinal fluid in the rabbit after cerebral anoxia induced by clamping].
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[Beta-glucuronidase activity in the amniotic fluid, cord blood and maternal blood serum in the course of normal deliveries and those complicated by fetal hypoxia].
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Reference genes for expression studies in hypoxia and hyperglycemia models in human umbilical vein endothelial cells.
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Human umbilical vein endothelial cell (HUVEC)-based gene expression studies performed under hypoxia and/or hyperglycemia show huge potential for modeling endothelial cell response in cardiovascular disease and diabetes. However, such studies require reference genes that are stable across the whole
Hypobaric-hypoxia induces alteration in microbes and microbes-associated enzyme profile in rat colonic samples.
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Present study deals with the straight impact of hypobaric hypoxia on the quantity and composition of some predominant fecal microflora and its functional aspects. For that, isolated fecal contents of rat were exposed to two different simulated air pressures (70 kPa and 40 kPa) for different time
Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia.
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Many enzyme activities in Alzheimer's disease (AD) are changed. Some of these enzyme activities are related to certain neurotransmitter systems. Enzymes in the brain can also be sensitive to antemortem hypoxia. In the present study it was determined if enzyme activities that are altered in AD are
Molecular characterization and promoter analysis of the maize cytosolic glyceraldehyde 3-phosphate dehydrogenase gene family and its expression during anoxia.
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Maize cytosolic glyceraldehyde-3-phosphate dehydrogenase (GAPC) is encoded by a small multi-gene family consisting of gpc1, gpc2, gpc3 and gpc4. GAPC3/4 protein is synthesized in roots during anoxic conditions and is known to be one of the 'anaerobic polypeptides'. We further analyzed the gpc gene
Anticancer prodrugs for application in monotherapy: targeting hypoxia, tumor-associated enzymes, and receptors.
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In order to improve current chemotherapeutic treatment and diminish severe side effects, several prodrug strategies have evolved to achieve site-specific delivery of cytotoxic anticancer agents. This review concentrates on recent developments of antitumor prodrug monotherapy with prodrugs that are
Modulation of small intestinal homeostasis along with its microflora during acclimatization at simulated hypobaric hypoxia.
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At high altitude (HA) hypobaric hypoxic environment manifested several pathophysiological consequences of which gastrointestinal (GI) disorder are very common phenomena. To explore the most possible clue behind this disorder intestinal flora, the major player of the GI functions, were subjected
Effect of oxygen free radicals, hypoxia and pH on the release of liver lysosomal enzymes.
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We investigated the effect of acidic environment, hypoxia and oxygen free radicals on the release of beta-glucuronidase from rat liver lysosomes. A lysosomal enriched fraction from the homogenate of rat liver was prepared, using differential centrifugation technique. Exogenous oxygen free radicals
The effect of anoxia on cerebral acid hydrolases in the five-day-old rat.
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1. Five-day-old anaesthetized rats subjected to slow, prolonged asphyxia (50-55 min) were either allowed to die or resuscitated when at the point of death. Activities of various cerebral acid hydrolases known to be associated with lysosomes were determined in these animals and in littermate
Heparanase expression in gallbladder carcinoma and its correlation to prognosis.
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OBJECTIVE
Heparanase is an endo-beta-glucuronidase that cleaves heparan sulfate and has been implicated in tumor angiogenesis and metastasis. The present study was to analyze the expression of and explore the prognostic value of heparanase and two important transcriptional factors, namely
Flavones and flavonols may have clinical potential as CK2 inhibitors in cancer therapy.
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The serine-threonine kinase CK2, which targets over 300 cellular proteins, is overexpressed in all cancers, presumably reflecting its ability to promote proliferation, spread, and survival through a wide range of complementary mechanisms. Via an activating phosphorylation of Cdc373, a co-chaperone
Morphology and mitochondrial function of the surviving myocardium following myocardial infarction in the cat.
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The surviving myocardium of the cat was studied 7 days and 6 weeks following experimental infarction. Seven days after infarction, ultrastructural alterations of the mitochondria indicative of slight hypoxic injury--clearing of the matrix and loss of dense matrix granules--were found. Together with
Intracellular and subcellular oedema and dehydration.
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Changes in intracellular water content appear to be common abnormalities induced by a wide variety of pathogenic mechanisms. Such changes in cell water produce changes in the water in various subcellular organelles bound by semipermeable membranes. Cell and subcell functions then alter in their
Aortic enzymes and lactate in high altitude-raised and cholesterol-fed rabbits.
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Fourteen male rabbits born at elevation 4000 ft (first experimental series) were transferred at age of 2 months to elevation 12470 ft and raised there for 18 weeks. Half of the animals remained on a commercial rabbit chow (group H) while the other half was on the same diet supplemented with
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