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bronchopulmonary dysplasia/hypoxia
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Automatic Oxygen Control for Reducing Extremes of Oxygen Saturation (AreOS): A Randomised Control Trial
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Supplemental oxygen remains by far the most commonly used 'drug' in neonatal intensive care units. The goal of oxygen therapy is to maintain normal oxygenation while minimizing hypoxemia and hypoxemia. Preterm infants are particularly vulnerable to oxygen toxicity and oxidative stress leading to
Effect of a Parenteral Emulsion With Omega3 on PPHN
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Background. Persistent pulmonary hypertension of the newborn (PPHN), is a syndrome characterized by difficulty to provide normal pulmonary vasodilatation at birth or after birth, which may be related with right ventricular dysfunction, congenital diaphragmatic hernia, sepsis, and meconium
30% or 60% Oxygen at Birth to Improve Neurodevelopmental Outcomes in Very Low Birthweight Infants
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Purpose: Over the last 10 years, recommendations regarding the ideal level of oxygen for resuscitation in preterm infants have changed from 100 percent, down to low levels of oxygen (<30 percent), up to moderate concentration (30-65 percent). In addition, in 2010, oxygen saturation targeting was
Safeguarding the Brain of Our Smallest Infants Phase III
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Background Each year, 50,000 extremely preterm infants are born in high-income countries with access to neonatal intensive care. Of these, 10,000 will die and a further 10,000 will suffer cerebral palsy or moderate-to-severe neuro-cognitive disability. Time spent outside normal cerebral oxygenation
Comparison of Automated Oxygen Control With and Without Automated Pressure Control in Preterm Ventilated Infants.
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Supplemental oxygen remains by far the most commonly used 'drug' in neonatal intensive care units. The goal of oxygen therapy is to maintain normal oxygenation while minimizing hyperoxaemia and hypoxemia. Preterm infants are particularly vulnerable to oxygen toxicity and oxidative stress leading to
The Hilo Trial to Improve Neurodevelopmental Outcomes in Very Low Birthweight Infants - Pilot-trial
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Purpose: Over the last 10 years, recommendations regarding the ideal level of oxygen for resuscitation in preterm infants have changed from 100%, down to low levels of oxygen (<30%), up to moderate concentration (30-65%). In addition, in 2010, oxygen saturation targeting was recommended as standard
Local Version of the Multi-center PREVENT Study Evaluating Cardio-respiratory Instability in Premature Infants
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The broad long-term objective is to use comprehensive state-of-the-art, high-fidelity monitoring to investigate physiological biomarkers of autonomic neurorespiratory maturation with integrated analysis of autonomic nervous system (ANS) responses in preterm infants, and to evaluate their role in
Intermittent Hypoxia and Caffeine in Infants Born Preterm
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Acute morbidities can contribute to adverse neurodevelopment outcomes in preterm infants born at ≤30 wks gestation, but neural damage occurring after resolution of acute morbidities may be more subtle and related to cycles of inflammation and repair in the developing brain. One possible contributor
Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus
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The ductus arteriosus is an essential blood vessel that connects the pulmonary artery and the aorta in the fetus. The patent ductus arteriosus (PDA) allows oxygenated blood that returns from the placenta to bypass the lungs and supply the fetal systemic circulation. In fetal life, ductus remains
Study to Justify Steroid Use in Preterm Neonates to Prevent Bronchopulmonary Dysplasia
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This is a prospective study. 30 Preterm infants admitted to neonatal intensive care units of Maadi, Ghamra military hospitals, and Ain Shams University hospitals, will be prospectively enrolled within 24 hours after birth. Daily evaluation of oxygen histograms with measurement of the cumulative time
Proper Pressure and Duration of Sustained Lung Inflation in Preterm Infants
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This study will be a randomized prospective pilot study in Mansoura University Hospital then the cases were followed at Neonatal Intensive Care Unit in Mansoura University Children Hospital, Mansoura, Egypt.
Preterm infants born equal to or less than 32 weeks gestation with respiratory distress
Analysis of the Impact of Patent Ductus Arteriosus on Brain Function in Preterm Neonates: Multimodal Approach Integrating EEG-NIRS, Ultrasound and Clinical Data
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The Anti-inflammatory Effect of Prophylactic Macrolides on Children With Chronic Lung Disease
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STUDY DESIGN AND METHODS
Overview:
This pilot randomized control trial (RCT) will enroll 92 children from 6 months to 6 years of age that have chronic lung disease (CLD) such as bronchopulmonary dysplasia during two pulmonary illness seasons. If the minimum number of patients (n=92) in Season 1 is
The Effects of Sound Energy on Pulmonary Gas Exchange
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Sound waves are used in various industries to accelerate the process of mixing or separating fluids (gases/liquids). We have proved that certain sound waves can safely improve gas exchange in the lung of rats through accelerating gas diffusion inside their airways and alveoli. Now we want to see if
Transpyloric Feeding in Severe Bronchopulmonary Dysplasia
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