Newborn Respiratory Distress

Preterm Infant

Non invasive ventilation technique in which PIP and PEEP administration is not synchronized with newborn's respiratory efforts

NIPPV

Non invasive ventilation technique in which PIP and PEEP administration is synchronized with newborn's respiratory efforts through an algorithm based on flow detection

sNIPPV

Ospedale S.Anna di Torino

Short Term Effects of Synchronized vs. Non-synchronized NIPPV in Preterm Infants.

Short Term Effects of Synchronized vs. Non-synchronized Nasal Intermittent Positive Pressure Ventilation in Preterm Infants. A Randomized Crossover Study.

cardio-respiratory events are defined as:
Hypoxic episodes (SatO2 < 80% for at least 4 seconds)
Apneas episodes (absence of breath for at least 20 sec or at least 5 sec if associated to hypoxia or bradycardia)
Bradycardia episodes (heart rate <80 bpm)

necessity of endotracheal intubation (FiO2 >40% and/or apnea episodes and/or increasing pCO2)

Possible indicators:
gestational age at birth birth weight delivery type APGAR at 1/5 minutes (and 10 minutes if effectuated) steroid prenatal prophylaxis surfactant administration type and duration of MV previously administered (if any) type and duration of NIV previously administered (if any) corrected gestational age at enrolling caffeine doses administered (if any) FiO2 maintained during monitoring EGA values at start and end of monitoring

Francesco Cresi, MD, PhD

MD, PhD

University of Turin, Italy

Participant will receive caffeine citrate 20mg/kg IV within 2 hours of life and placebo (normal saline IV) at 12 hours of life. Both infusions will be of identical volumes and appearance, and will be administered over 30 minutes.

Participant will receive placebo (normal saline IV) within 2 hours of life and caffeine citrate 20mg/kg IV at 12 hours of life. Both infusions will be of identical volumes and appearance, and will be administered over 30 minutes.

BPD - Bronchopulmonary Dysplasia

Apnea of Prematurity

Hemodynamic Instability

Intubation

The intervention in this study is timing of the initial caffeine dose. In the Caffeine arm, participants will receive Caffeine Citrate 20mg/kg IV (volume dose 1ml/kg) within 2 hours of life, and Normal Saline (0.9% NaCl) 1ml/kg IV at 12 hours of life.

Caffeine Citrate

The intervention in this study is timing of the initial caffeine dose. In the Placebo arm, participants will receive Normal Saline (0.9%NaCl) 1ml/kg IV within 2 hours of life, and Caffeine Citrate 20mg/kg IV (volume dose 1ml/kg) at 12 hours of life.

Placebo (Normal Saline)

Hollywood Presbyterian Medical Center

LAC+USC Medical Center

Early Caffeine in Preterm Neonates

A Randomized, Placebo-controlled Trial of Early Caffeine in Preterm Neonates

Need for endotracheal intubation within the first 12 hours of life.

Changes in cardiac output after administration of caffeine.

Jennifer Shepherd

Assistant Professor of Clinical Pediatrics

The Gerber Foundation

Each participant is assigned to one of two arms of the study.

The participant and participant's parents, medical care providers, and investigators will remain masked to the randomization.

Infants in Group A were cycled between NCPAP and nasal prongs. For the first 12 hours, infants received 10 hours of NCPAP and 2 hours of 1 litre per minute of nasal prongs (NP). For the next 12 hours, infants received 8 hours of NCPAP and 4 hours of NP. In the subsequent 24 hours, infants alternated between 6 hours of NCPAP and 6 hours of NP. In the last 24 hours of intervention they alternated between 4 hours of NCPAP and 8 hours of NP.

Infants randomized to group B received continuous NCPAP at a CPAP distending pressure of 4 cm of water for 72 hours. Both the groups after 72 hours of intervention were weaned to 1litre per minute NP. During the intervention period all infants were scored using the ACoRN respiratory score on a 12 hourly basis.

Premature Birth

NCPAP cycling

NCPAP continuous

Foothills Medical Centre, Room C211, 1403 - 29th Street NW

E-23596 - Use of NCPAP Cycling to Wean Preterm Infants

Randomised Controlled Trial to Study the Effect of Nasal Continuous Positive Airway Pressure (NCPAP) Cycling on Successful Weaning When Compared With Nasal Continuous Positive Airway Pressure (NCPAP) in Premature Infants of 25-28 Weeks Gestation

Primary outcome was successful weaning off NCPAP at the end of 72 hours of the intervention and remained off NCPAP for the next 72 hours

bronchopulmonary dysplasia/træthed

Short Term Effects of Synchronized vs. Non-synchronized NIPPV in Preterm Infants.

Early Caffeine in Preterm Neonates

E-23596 - Use of NCPAP Cycling to Wean Preterm Infants

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