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5 resultater
Mutational analysis of BRCA2 in Spanish breast cancer patients from Castilla-Leon: identification of four novel truncating mutations.
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Mutations in BRCA1 and BRCA2 account for approximately 5% of the overall familial risk of breast cancer. We have carried out a mutational analysis of the entire coding sequence of the BRCA2 gene in 150 breast cancer patients from Castilla-Leon by two different methods: Protein Truncation Test (PTT)
[Molecular study of the BRCA1 and BRCA2 genes in 153 breast cancer families from Castilla and León (Spain): new nine unclassified variants identified].
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BACKGROUND
It is estimated that 5-10% of breast cancers have an hereditary origin, germline mutations of BRCA1 and BRCA2 genes causing a predisposition. In the present study we analyzed BRCA1 and BRCA2 mutations in moderate to high risk breast cancer patients in order to find out the types and
[Program of early detection of breast cancer in Castilla-la-Mancha. Preliminary data of the first 5 months of performance. Regional Group on the Evaluation of the Program of Early Detection of Breast Cancer].
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BACKGROUND
A Breast Cancer Screening Programme managed by the Regional Ministry of Health in Castilla-La Mancha (Spain) was started in November 1992 in two districts. The purpose of this study is to describe the short-term results after five months of running.
METHODS
METHODS
descriptive,
[Breast cancer mortality in Castilla-La Mancha (1975-1990)].
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High proportion of novel mutations of BRCA1 and BRCA2 in breast/ovarian cancer patients from Castilla-León (central Spain).
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A total of 264 unrelated breast/ovarian cancer patients and 45 healthy individuals with familial antecedents referred for genetic testing were scanned for germ-line mutations in BRCA1 and BRCA2 by conformation-sensitive gel electrophoresis (CSGE) and heteroduplex analysis by capillary array
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