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High proportion of novel mutations of BRCA1 and BRCA2 in breast/ovarian cancer patients from Castilla-León (central Spain).

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A total of 264 unrelated breast/ovarian cancer patients and 45 healthy individuals with familial antecedents referred for genetic testing were scanned for germ-line mutations in BRCA1 and BRCA2 by conformation-sensitive gel electrophoresis (CSGE) and heteroduplex analysis by capillary array

Differences in incidence and survival to childhood cancer between rural and urban areas in Castilla y León, Spain (2003-2014): A Strobe-compliant study.

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The aim of this study is to describe childhood cancer incidence and survival in Castilla y León (Spain) for the period 2003 to 2014 and to explore differences between rural and urban areas.We made a cohort study in the childhood population of our region for the period of years referred before.

[Incidence of childhood cancer in the autonomous region of Castilla y León in Spain (2003-2007)].

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BACKGROUND Since 1980, childhood cancer cases have been registered in Spain in the National Registry of Childhood Cancer (based on hospital cases) and since 1990, five autonomous regions have had a population based registry. There is no specific registry of childhood cancer in Castilla y

Mutational analysis of BRCA2 in Spanish breast cancer patients from Castilla-Leon: identification of four novel truncating mutations.

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Mutations in BRCA1 and BRCA2 account for approximately 5% of the overall familial risk of breast cancer. We have carried out a mutational analysis of the entire coding sequence of the BRCA2 gene in 150 breast cancer patients from Castilla-Leon by two different methods: Protein Truncation Test (PTT)

[Molecular study of the BRCA1 and BRCA2 genes in 153 breast cancer families from Castilla and León (Spain): new nine unclassified variants identified].

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BACKGROUND It is estimated that 5-10% of breast cancers have an hereditary origin, germline mutations of BRCA1 and BRCA2 genes causing a predisposition. In the present study we analyzed BRCA1 and BRCA2 mutations in moderate to high risk breast cancer patients in order to find out the types and

[Program of early detection of breast cancer in Castilla-la-Mancha. Preliminary data of the first 5 months of performance. Regional Group on the Evaluation of the Program of Early Detection of Breast Cancer].

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BACKGROUND A Breast Cancer Screening Programme managed by the Regional Ministry of Health in Castilla-La Mancha (Spain) was started in November 1992 in two districts. The purpose of this study is to describe the short-term results after five months of running. METHODS METHODS descriptive,

[Malignant digestive tumor mortality in Castilla-La Mancha (1975-1990)].

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BACKGROUND The study investigates the temporary trend of the mortality by digestive malignant tumours in Castilla-La Mancha from 1975 to 1990. METHODS Standardized rates were calculated by direct method, using world and european population as standard, truncated rates (35-64 years old) and

Demographic, clinical, and genetic characteristics of patients with medullary thyroid cancer in the past 16 years in Castilla-La Mancha.

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OBJECTIVE Medullary thyroid cancer is a rare tumor that is more aggressive and has a worse prognosis than differentiated thyroid cancer. The purpose of this study was to report the demographic, clinical, and genetic characteristics of patients seen in the health care system of the community of

[Incidence of haematological neoplasms in Castilla y León, Spain].

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OBJECTIVE We aimed to assess the incidence of haematological neoplasms (HNs) in Castilla y León (2,5 million inhabitants) and its distribution by age, gender and histological type. METHODS The epidemiological profile based on the described variables of the 10,943 HNs diagnosed during a 10-years

Actual incidence of prostate cancer in healthcare areas of the autonomous community of Castilla-Leon during 2014. CAPCYL registry data.

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OBJECTIVE To determine the actual incidence of prostate cancer (PC) in the healthcare areas of Castilla-Leon in 2014. METHODS A multicentre study was conducted with the participation of 7 of the 9 healthcare areas of Castilla-Leon. We collected retrospective data that included 87.8% of the target

[Diagnostic and therapeutic management in a series of 1156 patients with the diagnosis of prostate cancer in Castilla y Leon during 2014.]

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To evaluate the current clinical practice for patients with Prostate Cancer (CP) in the Health Areas of Castilla y León (CyL) in 2014. METHODS: A retrospective multicenter study was designed to provide data on the diagnosis and treatment of PC in CyL: 87.8% of patients were screened.

[Incidence of bronchopulmonary cancer in Castilla y Leon and Cantabria in the year 2007. A study by the Castilla y Leon and Cantabria Respiratory Diseases Society (SOCALPAR)].

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BACKGROUND This study sets out to find out the incidence and other epidemiological characteristics of bronchopulmonary cancer in patients living in Cantabria and Castilla y Leon (Spain) and comparing the current data obtained in the last communities with that obtained 10 years ago in a similar

[Breast cancer mortality in Castilla-La Mancha (1975-1990)].

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Follow-up and results in patients with differentiated thyroid carcinoma in Castilla-La Mancha (2001-2015). The CADIT-CAM study.

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The CADIT-CAM study was designed to retrospectively analyze the clinical characteristics, treatments, and outcomes of patients with differentiated thyroid carcinoma (DTC) in Castilla La Mancha.A total of 1434 patients from 7 hospitals in Castilla La Mancha

[Mortality attributable to tobacco consumption in the years 1987 and 1997 in Castilla la Mancha, Spain].

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BACKGROUND Smoking is an important public health problem and is one of the main avoidable causes of morbidity and early mortality. The aim of this work was to describe the mortality attributable to tobacco consumption in Castilla la Mancha between 1987 and 1997. METHODS Deaths in relation to age,

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