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The role of chlorine atom on the binding between 2-phenyl-1H-benzimidazole analogues and fat mass and obesity-associated protein.
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In this work, nine 2-phenyl-1H-benzimidazole structural analogues were screened for potential inhibitor of the fat mass and obesity-associated protein (FTO) by isothermal titration calorimetry (ITC). The results show that the binding between 6-chloro-2-phenyl-1H-benzimidazole (1d) and FTO was
Preformulation characterization and in vivo absorption in beagle dogs of JFD, a novel anti-obesity drug for oral delivery.
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JFD (N-isoleucyl-4-methyl-1,1-cyclopropyl-1-(4-chlorine)phenyl-2-amylamine·HCl) is a novel investigational anti-obesity drug without obvious cardiotoxicity. The objective of this study was to characterize the key physicochemical properties of JFD, including solution-state characterization
Lung Function before and after a Large Chlorine Gas Release in Graniteville, South Carolina.
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BACKGROUND
On January 6, 2005 a train derailment led to an estimated 54,915-kg release of chlorine at a local textile mill in Graniteville, South Carolina.
OBJECTIVE
We used the employee health spirometry records of the textile to identify enduring effects of chlorine gas exposure resulting from the
Multi-element analysis of the obese subject by in vivo neutron activation analysis.
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The Leeds facility for in vivo neutron activation analysis has been modified and calibrated for the simultaneous measurement of nitrogen, potassium, sodium, chlorine, phosphorus and calcium in obese patients weighing up to 210 kg. The effects of body size and shape were incorporated into the
[Development of lipids and carbohydrates metabolism disorders caused by drinkable water with high content of chlorine organic compounds].
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Evaluation of effects caused by environmental peroral exposure to chlorine organic compounds revealed that individuals with AG variation of HTR2A gene are a community with increased sensitivity to chloroform and a risk group for lipid and carbohydrates metabolism disorders. Individual risk of
Difficulties in interpretation when assessing prolonged and subacute exposure to the toxic effects of chlorine.
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The purpose of this study was a toxicological interpretation of exposure to chlorine with unusual course. Medical, clinical and court records, as well as reviews of the literature, served as the basis for this interpretation. The first case of poisoning concerns a 52-year-old man who for a short
Identification of the disinfection byproducts of bisphenol S and the disrupting effect on peroxisome proliferator-activated receptor gamma (PPARγ) induced by chlorination.
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Bisphenol S (BPS), an alternative product to bisphenol A (BPA), has been the focus of increasing public concern due to its potential endocrine disrupting effect and its adverse effects related to metabolic disorders such as obesity. The detection of its residue in drinking water supply systems
Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations.
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We investigated cross-sectional associations of body composition and weight change with polychlorinated biphenyls (PCB) and organochlorine pesticides/pesticide metabolites measured in blood collected at the baseline of the Physical Activity for Total Health study of postmenopausal, overweight women
Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
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Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) have considerable potential as treatments for metabolic diseases, such as diabetes mellitus type 2 or obesity. Here, we report the discovery and synthesis of a series of novel benzothiazole derivatives and their
Long-term toxicity and carcinogenicity studies of cake made from chlorinated flour. 2. Studies in mice.
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Male and female Theiller's Original strain mice were fed for 16 and 17 months respectively on diets in which cake, prepared from flours treated with 0, 1250 or 2500 ppm chlorine, formed 79% by weight on a 12.6% moisture basis. Body weights and food intakes were unaffected by flour treatment but all
Effect of swimming on peak expiratory flow rate of atopic children.
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This study was conducted to evaluate the role of swimming on mechanic of lung in healthy individual and patients with asthma. A total 76 girls who took part in the course of regular swimming session three day per week for eight weeks enrolled in this study. All of them completed ISAAC written
Sucralose.
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Sucralose is a nonnutritive, zero-calorie artificial sweetener. It is a chlorinated sugar substitute that is about 600 times as sweet as sucrose. It is produced from sucrose when three chlorine atoms replace three hydroxyl groups. It is consumed as tablets (Blendy) by diabetic and obese patients. It
Design and Synthesis of Peroxisome Proliferator-activated Receptor (PPAR) Gamma Antagonists Based on the Principle of Operation of Nuclear Receptor I.
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Peroxisome proliferator-activated receptor γ (PPARγ) antagonist is a molecular target to create drug for the treatment of not only type 2 diabetes and obesity, but also cancer. However, few rational drug design strategies and concepts are available. Here, we utilized the nuclear receptor
[Isotopic study of fluid and electrolyte disturbances in decompensated chronic respiratory insufficiency (author's transl)].
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The study of fluid and electrolyte disturbances by isotope radiodilution method is carried out in 22 patients with chronic respiratory insufficiency and cardiac failure. The simultaneous measurements of hydro-ionic compartments have been carried out with tritiated water (HTO), labelled sodium
Probing the structural and topological requirements for CCR2 antagonism: holographic QSAR for indolopiperidine derivatives.
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CCR2 is the major family of chemokine receptors which involve in the pathophysiology of the acute or chronic inflammatory conditions such as rheumatoid arthritis, atherosclerosis, asthma, obesity, and type-2 diabetes. Herein, we report the results of HQSAR model, developed for CCR2 antagonistic
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