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colchicine/opkast
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Vomiting, diarrhea, and sudden death with recent southeast asian travel : Fatal colchicine toxicity.
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A 41-year-old male was referred for autopsy from a hospital with a diagnosis of sepsis of uncertain etiology. As he had recently been attached to a military base in Southeast Asia, and had only just returned home, there was considerable concern that an unknown infectious agent may have been
Colchicine exposures: the Texas experience.
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OBJECTIVE
Colchicine is a relatively uncommon toxin, but is known to precipitate severe multiorgan failure in overdose. Little is known about exposure patterns and outcomes in cases of colchicine ingestion. Our goal was to add to toxicologic knowledge through a database review and descriptive study
Death following colchicine poisoning.
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A 45-year-old male was admitted to hospital after 2 to 3 days of vomiting, nausea, and diarrhea following an apparent overdose of colchicine tables. During hospitalization his white blood cell count fell dramatically. At death, 33 h following initial hospitalization, pleural effusion with bilateral
Acute colchicine intoxication complicated with complete AV block.
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Colchicine, is an old and well-known drug, used for treatment of rheumatic diseases. Nausea, vomiting, abdominal pain, and diarrhea are the clinical symptoms of colchicine poisoning. Cardiotoxicity can lead to mortality. We report a case of colchicine intoxication complicated with complete heart
Fatal poisoning in children: acute colchicine intoxication and new treatment approaches.
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BACKGROUND
Colchicine poisoning is potentially life-threatening. Deaths generally result from hypovolemic shock and cardiovascular collapse or secondary to rapidly progressive multiorgan failure.
OBJECTIVE
The purpose of this study is to discuss the clinical effects, treatments and outcomes of
Colchicine poisoning complicated by medulla oblongata myelinolysis: a case report
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Medulla oblongata myelinolysis is an extremely rare manifestation of extrapontine myelinolysis (EPM). Herein, we report a case of a 34-year-old man with a history of gout who presented repeated vomiting and diarrhea after ingesting 15 colchicine pills. A hyponatremia diagnosis was given and after an
Survival case of colchicine intoxication following ingestion of a lethal dose.
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BACKGROUND
There have been few reports of cases where the ingestion of colchicine was utilized as a method of suicide and accordingly, its effect on the human body is not fully understood. It has been reported that all individuals who ingested more than 0.8 mg/kg of colchicine died of shock within
Evaluation of the Colchicine Poisoning Cases in a Pediatric Intensive Care Unit: Five Year Study.
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BACKGROUND
Colchicine poisoning is an uncommon but serious form of drug intoxication. It may produce life-threatening systemic effects. In toxic doses it produces nausea and vomiting and bone marrow suppression, often leading to sepsis, hypocalcemia, adult respiratory distress syndrome, and direct
Epithelial cell mitotic arrest--a useful postmortem histologic marker in cases of possible colchicine toxicity.
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Following ingestion of 30 mg of presumed benztropine (Cogentin) a 39-year-old male developed nausea, vomiting and diarrhea. His admission to hospital was soon followed by collapse and death. Histological examination, however, revealed increased numbers of mitotic figures in otherwise normal
Biomechanical measurement and analysis of colchicine-induced effects on cells by nanoindentation using an atomic force microscope.
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Colchicine is a drug commonly used for the treatment of gout, however, patients may sometimes encounter side-effects induced by taking colchicine, such as nausea, vomiting, diarrhea and kidney failure. In this regard, it is imperative to investigate the mechanism effects of colchicine on biological
Survival of a dog with accidental colchicine overdose.
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Acute Pediatric Colchicine Toxicity is Associated with Marked Bradydysrhythmias.
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Colchicine ingestion is rare but highly lethal. Patients usually die of multiorgan failure and cardiogenic shock. Colchicine is not only associated with depressed myocardial function but also with fatal heart rhythm disturbances, such as complete heart block, ventricular tachycardia, and asystole.
Clinical Manifestations and Outcomes of Colchicine Poisoning Cases; A Cross Sectional Study
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Introduction: Colchicine is a medication with narrow therapeutic index, leading to both accidental and suicidal poisonings incidents. This study aimed to investigate the clinical and laboratory manifestations, as well as outcomes of colchicine poisoning patients
[Recurrent bouts of fever accompanied by abdominal pain and emesis].
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A 34 year-old Turkish patient was admitted to hospital several times with the same symptoms of abdominal pain, fever up to 39.2 degrees C and vomiting. The diagnosis always was an acute attack of chronic pancreatitis. The inflammation scores in the blood were high and he had a moderate increase in
[Case of colchicine intoxication caused by tubers of Gloriosa superba].
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Gloriosa superba is one of the poisonous plants growing in Japan. It contains potent alkaloid such as colchicine which binds to tubulin and prevents it from forming microtubules that are part of the cytoskeleton in human cells. Ingestion of Gloriosa superba tubers causes severe and potentially fatal
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