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Colchicine for Stroke Prevention: A Systematic Review and Meta-analysis.

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There has been recent interest in the role of colchicine in cardiovascular diseases, given the implication of inflammation in the pathogenesis of atherothrombosis. This systematic review assessed the role of colchicine in preventing primary or secondary stroke/transient ischemic attack

Role of Colchicine in Stroke Prevention: An Updated Meta-Analysis.

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Colchicine is a microtubule inhibitor with anti-inflammatory properties. As the body and quality of evidence regarding the efficacy of colchicine for cardiovascular prevention is controversial, the aims of this study was to evaluate the effect of colchicine therapy on vascular

Colchicine for Stroke Prevention in Patients with Coronary Artery Disease: A Systematic Review and Meta-analysis.

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Although clinical trials suggest that colchicine may reduce risk of vascular events in patients with a history of coronary artery disease, its effect on the prevention of cerebrovascular events still remains unclear.We performed a systematic review and

Effect of colchicine compared with placebo on high sensitivity C-reactive protein in patients with acute coronary syndrome or acute stroke: a pilot randomized controlled trial.

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There is a need for more effective therapies to reduce morbidity and mortality from cardiovascular disease. Inflammation plays a central role in the pathogenesis of atherosclerosis but no randomized studies have evaluated anti-inflammatory therapy in patients with acute coronary or cerebrovascular

Optimisation of Stroke Prevention: Colchicine may be an option.

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Secondary prevention encompasses the reduction of further stroke and TIA, any other vascular disease, cognitive decline and dementia, mood disturbances and poor quality of life. Tailored secondary prevention applies to almost all patients with stroke or TIA and can reduce stroke recurrence by 80%.

Daily Colchicine Post-MI Reduces Strokes and Recurrent Hospitalizations for Angina

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Colchicine prevents stroke in patients with coronary artery disease - a trial sequential analysis.

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I read with interest the recent meta-analysis by Katsanos et al.(1) The authors are to be applauded for their efforts and careful analysis. In view of the potential significance of the findings, a trial sequential analysis (TSA) was performed to assess the conclusiveness of the presented evidence.

Colchicine in Post-operative Atrial Fibrillation: A Review.

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Post-operative atrial fibrillation (POAF) is a frequent entity increasing hospitalization duration, stroke and mortality. In the recent years, a few studies have sought to investigate the potential effect of colchicine in POAF prevention after cardiac surgery or catheter pulmonary vein isolation for

Rationale and design of the COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 trial): a randomized, placebo-controlled, multicenter study on the use of colchicine for the primary prevention of the postpericardiotomy syndrome, postoperative effusions, and postoperative atrial fibrillation.

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BACKGROUND The efficacy and safety of colchicine for the primary prevention of the postpericardiotomy syndrome (PPS), postoperative effusions, and postoperative atrial fibrillation (POAF) remain uncertain. Although preliminary data from a single trial of colchicine given for 1 month postoperatively

The Role of Colchicine in the Prevention of Cerebrovascular Ischemia.

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BACKGROUND Despite the proven efficacy of anti-thrombotic, lipid-lowering, anti-hypertensive therapies and lifestyle modification changes for secondary ischemic stroke prevention, the risk of recurrent stroke, coronary events and vascular death remains substantial even for patients treated with high

Colchicine affects cortical and amygdalar neurochemical changes differentially after middle cerebral artery occlusion in rats.

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Recently, we have shown increases in the immunoreactivity for neuropeptide Y and tyrosine hydroxylase in the insular cortex surrounding the focal infarction after middle cerebral artery occlusion. In addition, the immunoreactivity for neuropeptide Y, leucine-enkephalin, dynorphin, and neurotensin

Safety and efficacy of colchicine in patients with coronary artery disease: A systematic review and meta-analysis

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Background: Given current evidence, the use of colchicine for the prevention of adverse cardiovascular events in patients with coronary artery disease (CAD) remains controversial. Methods:

Colchicine therapy in patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials

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Introduction: Inflammation is a substantial mediator of atherosclerosis. Colchicine has anti-inflammatory effects and has been investigated in many randomized controlled trials (RCTs) in patients with coronary artery disease

Colchicine in Neurosurgery.

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BACKGROUND Colchicine is an ancient drug. Many uses have been reported in medical books and reports through the centuries. Currently the understanding of its mechanism of action has opened new horizons to its use. OBJECTIVE This article aims to discuss the use of colchicine in various neurosurgical

Effects of colchicine on risk of cardiovascular events and mortality among patients with gout: a cohort study using electronic medical records linked with Medicare claims.

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Colchicine may have beneficial effects on cardiovascular (CV) disease, but there are sparse data on its CV effect among patients with gout. We examined the potential association between colchicine and CV risk and all-cause mortality in gout. The analyses used data from an electronic medical record

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