diabetic ketoacidosis/tyrosine

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Brain transmitter precursors and metabolites in diabetic ketoacidosis.

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Patients studied during recovery from an episode of ketoacidotic diabetes had raised blood glucose, plasma free fatty acid and plasma free tryptophan concentrations. Plasma total tryptophan was decreased. Well controlled diabetics showed normal values. The ketoacidotic patients had increased lumbar

Profiles in altered metabolism I--the organic acids accumulating in acute non-diabetic ketoacidosis associated with alcoholism.

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Several organic acids, among them the acidic catabolites of the branched chain amino acids and tyrosine, have been found to be elevated in the sera of non-diabetic patients presenting acute ketoacidosis associated with alcohol abuse. These findings are interpreted in terms of insufficiency of

Changes in the gastric enteric nervous system and muscle: a case report on two patients with diabetic gastroparesis.

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BACKGROUND The pathophysiological basis of diabetic gastroparesis is poorly understood, in large part due to the almost complete lack of data on neuropathological and molecular changes in the stomachs of patients. Experimental models indicate various lesions affecting the vagus, muscle, enteric

[Subclassification of seronegative type 1 diabetic subjects with HLA-DQ genotypes].

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OBJECTIVE To reveal the relationship between disease phenotype and HLA-DQ genotype in autoantibody-negative type 1 diabetics and to explore whether HLA-DQ genotypes can reclassify seronegative type 1 diabetic patients. METHODS Sixty-one diabetics with unprovoked ketosis or ketoacidosis at

[Use of ABC typing to redefine subtypes of acute-onset type 1 diabetes mellitus: study of 308 patients].

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OBJECTIVE To investigate the feasibility of ABC typing to redefine the subtypes of acute-onset type 1 diabetes mellitus (DM). METHODS Radioligand assay was used to detect glutamic acid decarboxylase-antibody (GAD-Ab) and tyrosine phosphatase autoantibody (IA-2A) in 308 patients with acute-onset type

Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes.

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OBJECTIVE Autoantibodies directed against tyrosine phosphatase IA-2 antibody (IA-2 Ab) are diagnostic for autoimmune type 1 diabetes. Conventional assays target the intracellular domain of IA-2. Among patients with ketosis-prone diabetes (KPD), characterized by presentation with diabetic

The PTPN22 C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes.

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BACKGROUND The protein tyrosine phosphatase nonreceptor type 2 (PTPN22) has been established as a type 1 diabetes susceptibility gene. A recent study found the C1858T variant of this gene to be associated with lower residual fasting C-peptide levels and poorer glycemic control in patients with type

Ketoacidosis in young adults is not related to the islet antibodies at the diagnosis of Type 1 diabetes mellitus--a nationwide study.

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OBJECTIVE To test the hypothesis that there is lower prevalence of islet antibodies in subjects with newly diagnosed Type 1 diabetes mellitus in young adulthood than in children is associated with less severe diabetes at time of diagnosis. METHODS This investigation was based on a nationwide study

Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.

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BACKGROUND Pheochromocytoma is a catecholamine-producing tumor that originates from adrenal chromaffin cells and is capable of secreting various hormones, including ACTH. METHODS A 56-year-old female presented with Cushingoid appearance and diabetic ketoacidosis. Endocrinological examinations

Plasma amino acid levels in hyperosmolar nonketotic diabetic coma.

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The plasma amino acid levels in five patients with hyperosmolar nonketotic diabetic coma and in seven normal subjects were analysed. In the patients with hyperosmolar nonketotic diabetic coma, total amino acids were generally low, especially, the concentrations and the molar ratios of arginine,

Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report

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Here we report a case where the manifestations of insulin-dependent diabetes occurred following SARS-CoV-2 infection in a young individual in the absence of autoantibodies typical for type 1 diabetes mellitus. Specifically, a 19-year-old white male presented at our emergency department with diabetic

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