Danish
Albanian
Arabic
Armenian
Azerbaijani
Belarusian
Bengali
Bosnian
Catalan
Czech
Danish
Deutsch
Dutch
English
Estonian
Finnish
Français
Greek
Haitian Creole
Hebrew
Hindi
Hungarian
Icelandic
Indonesian
Irish
Italian
Japanese
Korean
Latvian
Lithuanian
Macedonian
Mongolian
Norwegian
Persian
Polish
Portuguese
Romanian
Russian
Serbian
Slovak
Slovenian
Spanish
Swahili
Swedish
Turkish
Ukrainian
Vietnamese
Български
中文(简体)
中文(繁體)
early/scopolamine
Linket gemmes på udklipsholderen
Side 1 fra 212 resultater
The scopolamine model as a pharmacodynamic marker in early drug development.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
BACKGROUND
Drug development is a high-risk and high failure enterprise, and studies that provide an early read on the pharmacodynamic activity of novel compounds could save time and money, increasing the efficiency of the drug development process.
OBJECTIVE
Preclinical and clinical experiments were
[Effect of early administration of scopolamine on spinal cord injury: an experimental study].
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
Pharmacodynamic and early clinical studies with velnacrine.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
The paper reviews the results obtained with velnacrine, a cholinesterase inhibitor and potential Alzheimer's disease agents, in early clinical studies in healthy volunteers and patients with probable Alzheimer's disease (AD). In healthy subjects, the compound was demonstrated to reverse cognitive
Effects of early protein malnutrition and scopolamine on learning and memory in the Morris water maze.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
The present study investigated the effects of early protein malnutrition on the spatial learning and memory processes. The consequences of malnutrition for the cholinergic system were evaluated by comparing the performance of malnourished and control animals in the Morris water maze after treatment
Early human trials in the assessment of cognition activators.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
The assessment of cognition enhancers in the clinic is a broad topic that can be addressed from both academic/theoretical and therapeutic/drug development perspectives. The most important first step is to decide which perspective one is employing and to clearly specify, a priori, the goal of any
A rapid recovery program: early home and pain free.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
Enhancement of our perioperative pain management protocols has resulted in accelerated rehabilitation. At our facility, the majority of patients undergoing total and partial knee arthroplasty are treated with a single-shot spinal anesthetic consisting of a combination of bupivacaine and duramorph.
Early clinical testing of cognition enhancers: prediction of efficacy.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
The major problem in predicting clinical efficacy from animal experimental results and phase I data is the lack of resemblance between the models used and the clinical condition. This problem is complicated by the diversity of the potential mechanisms of action of new compounds. A further question
Persistent neurobehavioral effects of early postnatal domoic acid exposure in rats.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
Domoic acid (DA) is a marine biotoxin, produced by the diatom Pseudo-nitzchia spp., which has been shown to cause cognitive impairment in adults who are exposed via contaminated seafood. The neurobehavioral consequences of developmental exposure are much less well understood. In a previous study, we
Prolonged behavioral effects of early postnatal lead exposure in rhesus monkeys: fixed-interval responding and interactions with scopolamine and pentobarbital.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
Three groups of rhesus monkeys (N = 4/group) were administered daily doses of lead acetate dissolved in milk throughout the first year of life. The doses of lead administered were 0.9 mg/kg/day (high lead group), 0.3 mg/kg/day (low lead group), and no added dietary lead (control group). These doses
Influence of thiopental anaesthesia on fetal motor behaviour in early pregnancy.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
Real-time ultrasonography has shown fetal motor activity to be present long before the mother is able to perceive any movements. The development of fetal movement patterns reflects neuromotor maturation of the fetal central nervous system. Drugs given to the mother may affect fetal neuromotor
Epigenetic regulation of neuronal immediate early genes is associated with decline in their expression and memory consolidation in scopolamine-induced amnesic mice.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
Recently, we reported a correlation of scopolamine mediated decline in memory consolidation with increase in the expression of DNA methyltransferase 1 (DNMT1) and histone deacetylase 2 (HDAC2) in the mouse hippocampus. Memory consolidation is a protein synthesis-dependent process which involves the
Correction to: Epigenetic regulation of neuronal immediate early genes is associated with decline in their expression and memory consolidation in scopolamine-induced amnesic mice.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
The original article inadvertently had a mistake in Fig. 3a and b. The authors regret to these errors.
Evidence for synergistic modulation of early information processing by nicotinic and muscarinic receptors in humans.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
Impairments in early information processing are a hallmark feature of diverse neuropsychiatric disorders including schizophrenia and Alzheimer's disease (AD). Several lines of evidence implicate a dysfunction of the cholinergic system in these disorders, particularly in AD where there is known
The politics of female pain: women's citizenship, twilight sleep and the early birth control movement.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
The medical intervention of 'twilight sleep', or the use of a scopolamine-morphine mixture to anaesthetise labouring women, caused a furore among doctors and early 20th-century feminists. Suffragists and women's rights advocates led the Twilight Sleep Association in a quest to encourage doctors and
NMDA receptor-dependent and -independent immediate early gene expression induced by focal mechanical brain injury.
Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
In the present study we analysed, by in situ hybridization, the effects of an extremely localized mechanical brain injury, obtained by the simple needle insertion (30 g) in rat hippocampus or cortex, on the expression of several immediate early genes (c-fos, fosB, c-jun, junB, junD, zif/268). When
Den mest komplette database med medicinske urter understøttet af videnskab
- Arbejder på 55 sprog
- Urtekurer, der understøttes af videnskab
- Urtegenkendelse ved billede
- Interaktivt GPS-kort - tag urter på stedet (kommer snart)
- Læs videnskabelige publikationer relateret til din søgning
- Søg medicinske urter efter deres virkninger
- Organiser dine interesser og hold dig opdateret med nyhedsundersøgelser, kliniske forsøg og patenter
Skriv et symptom eller en sygdom, og læs om urter, der kan hjælpe, skriv en urt og se sygdomme og symptomer, den bruges mod.
* Al information er baseret på offentliggjort videnskabelig forskning
