group is subdivided into 2sub-groups: Group 1: Group: underwent PCI(Primary or Rescue) Group 2: underwent CABG Patients diagnosed as multivessel disease or left main coronary artery lesion will be included in the study

Diabetes Mellitus, Type 2 With Acute Coronary Syndrom

II-PCI:
-Coronary angiography and intervention will be done according to the European guidelines of ACS revascularization.
III-CABG:

with percutaneous coronary intervention (PCI) are with new-generation drug-eluting stents (DES)

(2018) 17:151 Impact of type 2 diabetes mellitus on short- and long-term mortality after coronary artery bypass surgery

2018. PCI or CABG in Stable Patients With Multivessel CAD and Diabetes

Left ventricular metabolic remodeling and accompanied dysfunction in type 2 diabetic patients: A 3D speckle tracking analysis

Predictors of Coronary Revascularization Outcomes in Type 2 Diabetic Patients With Acute Coronary Syndrome

Rate of myocardial infarction (MI), Rate of revascularization, Rate of cerebrovascular events"stroke"

Rate of death (mortality rate)after CABG or PCI

Rabab Emad Ahmed Mohmed Mashhour

Assistant lecturer of internal medicine

Assiut University

generic name：telmisartan；dosage form：80 mg；dosage：80 mg；frequency：once a day；duration：June , 2019-June , 2021

generic name： amlodipine；dosage form：5mg；dosage：5mg；frequency：once a day；duration：June , 2019-June , 2021

Hypertension

Telmisartan group: telmisartan 80 mg once a day

telmisartan

amlodipine group: amlodipine 5 mg once a day

amlodipine

First Affiliated Hospital of Xi'an Jiaotong University

Clinical Efficacy of Telmisartan in Reducing Cardiac Remodeling Among Obese Patients With Hypertension

A Cohort Study of Telmisartan on Metabolic Components and Left Ventricular Remodeling in Obese Patients With Hypertension

Revascularization for myocardial infarction and unstable angina pectoris

First Affiliated Hospital Xi'an Jiaotong University

A standard ECP protocol involves 35 one-hour sessions (once per day, 5 days a week) and continuous for 7 weeks. ECP consists of three sets of pneumatic cuffs attached to each of the patient's legs at the calf and lower and upper thigh. The inflation of the cuffs is triggered by a computer, and timing of the inflation is based on the R wave of the electrocardiogram. The ECP therapist adjusts the inflation and deflation timing to provide optimal blood movement per a finger plethysmogram waveform reading.

Guideline-driven standard medical treatment

Ischemic Stroke

standard ECP protocol involves 35 one-hour sessions (once per day, 5 days a week) and continuous for 7 weeks. ECP consists of three sets of pneumatic cuffs attached to each of the patient's legs at the calf and lower and upper thigh. The inflation of the cuffs is triggered by a computer, and timing of the inflation is based on the R wave of the electrocardiogram. The ECP therapist adjusts the inflation and deflation timing to provide optimal blood movement per a finger plethysmogram waveform reading.

External counter pulsation (ECP)

Shenzhen Research Institute, The Chinese University Hong Kong

The Second Affiliated Hospital of Zhengzhou University

The Second Affiliated Hospital of Xi'an Jiaotong University

Effect of External Counter Pulsation on Ischemic Stroke

Effect of External Counter Pulsation on IschemicStroke (ECP-STROKE)

Ischemic area of 3-month Cerebral CT image

transcranial doppler (TCD) flow velocities

Guifu Wu

Eighth Affiliated Hospital, Sun Yat-Sen University

Eighth Affiliated Hospital, Sun Yat-sen University

Second Affiliated Hospital of Xi'an Jiaotong University

Patients with Gaucher disease or high-grade suspicion for Gaucher disease

For the development of the new biomarkers using the technique of Mass-spectrometry, maximal 10 ml blood will be taken via using a dry blood spot filter card and will be ana-lysed. (Optionally, also 10 ml urine will be taken via urine-collection tube). To proof the correct Gaucher diagnosis in those patients where up to the enrollment in the study no genetic testing has been done, sequencing of Gaucher will be done. The analyses will done at: Centogene AG Am Strande 7 18055 Rostock Germany

Splenomegaly

Hepatomegaly

CENTOGENE is a worldwide leader in the field of genetic diagnostics for rare hereditary diseases - with the largest test portfolio worldwide.

Centogene AG

Amrita Institute of Medical Sciences & Research Centre

Navi Mumbai Institute of Research In Mental And Neurological Handicap (NIRMAN)

Lady Ridgeway Hospital for Children

Biomarker for Gaucher Disease: BioGaucher (BioGaucher)

Biomarker for Gaucher Disease an International, Multicenter, Epidemiological Protocol

Next-Generation Sequencing (NGS) of the GBA gene will be performed. The mutation will be confirmed by Sanger sequencing.

The quantitative determination of small molecules (molecular weight 150-700 kD, given as ng/μl) within a dried blood spot sample will be validated via liquid chromatography multiple reaction-monitoring mass spectrometry (LC/MRM-MS) and compared with a merged control cohort. The statistically best validated molecule will be considered as a disease specific biomarker.

glycolipid/infarkt

Predictors of Coronary Revascularization Outcomes in Type 2 Diabetic Patients With Acute Coronary Syndrome

Clinical Efficacy of Telmisartan in Reducing Cardiac Remodeling Among Obese Patients With Hypertension

Effect of External Counter Pulsation on Ischemic Stroke

Biomarker for Gaucher Disease: BioGaucher (BioGaucher)

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