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Great expectations in stereochemistry: focus on antidepressants.

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Chirality has become an increasingly important consideration in the development of psychoactive drugs because enantiomers often show major differences in their pharmacokinetic and pharmacologic properties. This review illustrates the implications of stereochemistry in clinical psychopharmacology

Depression: the great imitator in family practice.

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Psychiatric problems, especially depression, are common in primary care and can usually be treated successfully by family physicians if the diagnosis is made. Unfortunately, there is as yet no simple, definitive test for detecting depression. Family physicians must be aware that depression is very

Economic suicides in the Great Recession in Europe and North America.

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There has been a substantial rise in 'economic suicides' in the Great Recessions afflicting Europe and North America. We estimate that the Great Recession is associated with at least 10 000 additional economic suicides between 2008 and 2010. A critical question for policy and psychiatric practice is

Review: maintenance antidepressants reduce risk of relapse but effect is not as great in recurrent depression.

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The great ambivalence: factors likely to affect service user and public acceptability of the pharmacogenomics of antidepressant medication.

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Whilst antidepressant medications are widely used, they are ineffective for nearly 40 per cent of users and cause numerous adverse drug reactions. The pharmacogenomics of depression attempts to better understand the role of genetic variation in antidepressant metabolism in the hope of improving drug

Trends in service use and treatment for mental disorders in adults throughout Great Britain.

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BACKGROUND Trends in health treatments and outcomes in the general population may be used to monitor achievement of health targets. OBJECTIVE To investigate changes in mental health services and treatment in Britain over a 7-year period. METHODS National surveys of psychiatric morbidity were

Gender and Race/Ethnicity Differences in Mental Health Care Use before and during the Great Recession.

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This study examines the changes in health care utilization for mental health disorders among patients who were diagnosed with depressive and/or anxiety disorders during the Great Recession 2007-2009 in the USA. Negative binomial regressions are used to estimate the association of the economic

Economic shocks, resilience, and male suicides in the Great Recession: cross-national analysis of 20 EU countries.

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BACKGROUND During the 2007-11 recessions in Europe, suicide increases were concentrated in men. Substantial differences across countries and over time remain unexplained. We investigated whether increases in unaffordable housing, household indebtedness or job loss can account for these population

Short-term effects of the 2008 Great Recession on the health of the Italian population: an ecological study.

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OBJECTIVE To report on the effects on health that the 2008 Great Recession is producing in Italy, by comparing the consistency of Italian data with general observations reported in the scientific literature, and by pointing out consequences on the rates of all-cause mortality, cardiovascular

Occupational health physicians and the impact of the Great Recession on the health of workers: a qualitative study.

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BACKGROUND Italy is one of the Eurozone members where the 2008 "Great Recession" struck worst, with a 9% drop in national GDP between 2008 and 2013. The negative effects of the recession on the health of the Italian population were documented on a nation-wide level. However, few local or regional

Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada.

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Prescription and nonprescription drugs have been detected in rivers and streams in Europe and the United States. Sewage treatment plants (STPs) are an important source of these contaminants, but few data exist on the spatial distribution of drugs in surface waters near STPs. Samples of surface water

How did the 2008-11 financial crisis affect work-related common mental distress? Evidence from 393 workplaces in Great Britain.

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This paper analyses how the 2008-11 financial crisis relates to work-related common mental distress of those with continuous employment during the crisis. The literature connecting the 2008-11 financial crisis to common mental distress (anti-depressant drug use, suicide, etc.) generally estimates a

How did the use of psychotropic drugs change during the Great Recession in Portugal? A follow-up to the National Mental Health Survey.

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Research suggests that economic recessions might be associated with a higher use of psychotropic drugs, but literature is scarce and contradictory in identifying the most vulnerable groups. This study aims to assess possible changes in the use of psychotropic drugs due to the economic

Metabolic drug interactions with selective serotonin reuptake inhibitor (SSRI) antidepressants.

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The selective serotonin reuptake inhibitor (SSRI) antidepressants have become an important component of the therapeutic armamentarium in psychiatry and have attracted a great deal of public attention. Another interesting aspect of the SSRIs is their interaction with various isozymes of the

[Antidepressants and the risk of bleeding].

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BACKGROUND By blocking the serotonin transporter system antidepressants can, in theory, result in bleedings. However, we do not yet know how great the risk of bleeding is and what the clinical implications are. OBJECTIVE To assess how great the risk of bleeding is and what the clinical implications

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