heliotrine/hepatitis

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[Enzymatic activity of the pancreas and small intestinal mucosa in modelling of toxic hepatitis by administration of heliotrine].

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The activity of pancreatic (alpha-amylase, protease, and lipase) and enteral (maltase, glycyl-L-leucine dipeptidase, monoglyceride lipase) was studied in the experiments on adult male Wistar rats weighting 350 +/- 35 g 1-3, 7, 10, 30, 60, and 90 days after injection of a single dose of 25 mg per 100

[Thymus changes in chronic heliotrine-induced hepatitis].

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The structural and morphometrical characteristics of thymus were studied in the dynamics of experimental heliotrine hepatitis. The decrease of areas and cell hypoplasia of cortical zone of the thymus were noted. The destructive processes of the thymocytes were intensified and, in response to it,

[State of oxidizing processes in rat liver in chronic heliotrine hepatitis].

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Parameters of oxidative phosphorylation, the rate of respiration in various metabolic states of rat liver mitochondria as well as activity of lactate-and malate dehydrogenases in blood serum were altered in rats with chronic heliotrine hepatitis. Cupir (copper containing complex substance)

Disturbances in oxidative phosphorylation in the liver of rats with heliotrine-induced hepatitis and restoration by phosphatidylcholine and ATP.

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Acute hepatitis induced by heliotrine is accompanied by uncoupling of oxidative phosphorylation in liver mitochondria. The rate of oxygen uptake during succinate oxidation increased in all metabolic states, while the respiratory control index decreased by 45% because of the greater increase in the

[Change in lipid peroxidation processes and level of individual gangliosides and phospholipids in the liver of rats with toxic experimental hepatitis].

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Content of individual phospholipids, gangliosides and lipid peroxidation were studied in liver tissue homogenates of rats with hepatitis caused by CCl4 or heliotrine. In all the cases studied the rate of lipid peroxidation was distinctly increased, while content of sphingomyelin was decreased and

[Some aspects of the formation of the immune system organs in newborn rats born to females with chronic hepatitis].

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The immune system organs formation and development was studied in 61 rat younglings born to pregnant animals with chronic toxic hepatitis. A comparative investigation permitted ascertaining that chronic heliotrine hepatitis in female rats results in an increased death rate in the progeny, the

[Effects of maternal toxic hepatitis on the postnatal development of duodenal morphology of their offspring].

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Retardation has been shown in development and formation of the vascular-and-tissue structures of white rat younglings (3, 7, 14, 21, 30 days old) born to mothers with chronic heliotrine hepatitis in the duodenum versus control animals. In the duodenal mucosa, the villi are short, their shape lost,

[Experimental and clinical evaluation of the efficacy of ecdysten in the treatment of hepatitis].

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The properties of ecdysten, an exdysterone-based preparation, were studied under experimental (of heliotrine induced hepatitis model in rats) and clinical (chronic viral hepatitis B) conditions. A 2-week treatment with ecdysten in a daily dose of 5 mg/kg (p.o.) significantly improved the state of

[Morphological characteristics of chronic toxic hepatitis treated with neoselen].

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The purpose of the given research work was to study the features of morphologic changes arising during the treatment of chronic hepatitis with NEOSELEN. Chronic active hepatitis was set up in laboratory rats, post-forming in chronic persisting hepatitis and its transformation in a certain part of

[Morphologic characteristic of chronic toxic hepatitis for treatment with Neoselen].

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The purpose of the given research work was to study the features of morphologic changes arising for treatment of chronic hepatitis with Neoselen. It was established a picture of chronic active hepatitis in the liver of rats with the following development of chronic persisting hepatitis by the 40

[Phosphatidylcholine-induced repair of damaged hepatocyte membranes in heliotrine poisoning].

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Hepatocyte membranes destruction in experimental toxic hepatitis caused by heliotrine administration was accompanied by a 10-fold increase in blood serum activity of aldolase fructose-I-monophosphate, a decrease in cytochrome P-450 content, an increase in the rate of cytochrome P-450 inactivation,

[Action of phytoecdysteroids on the bile-secretory function of the normal liver and in experimental hepatitis].

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Phytoecdysteroids from Rhaponticum carthemoides (Willd) Iljin and Ajuga turkestanica (Rgl.) Brig in a dose of 5 mg/kg per os markedly stimulate the bile secretion in normal rats treated with single (cyasterone) and 7-day-long (ecdysterone, cyasterone) administration. The chemical composition of the

[Correction of the lipid composition of the liver plasma membranes during heliotrine intoxication].

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Antioxidant properties of yantocine, a preparation derived from Alhagi pseudalhagi Desy, were studied on a model of acute toxic hepatitis induced in random bred young male albino rats (90-100 g). Two experimental models were used: acute geliotrine hepatitis and acute CCl4 hepatitis. Yantocine was

[Effect of maternal toxic hepatitis on the functional characteristics of the lactation process].

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The authors have studied the influence of chronic heliotrine intoxication on female rats subjected to it before their pregnancy and on the quantity of proteins, carbohydrates, activity of enzymes and immunocompetent cells (ICC) of rats milk during the period of breast feeding. Decrease in an amount

Preincubation format for a sensitive immunochromatographic assay for monocrotaline, a toxic pyrrolizidine alkaloid.

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Monocrotaline (MCT), which is classified as a 1,2-dehydropyrrolizidine alkaloid (DHPA), is a toxic compound that is mainly produced by Crotalaria spp. MCT contamination in cereals and herbs leads to hepatitis, gastroenteritis, pulmonary vasculitis and hypertension, and different types

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