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Compounds and methods for treating insulin resistance and cardiomyopathy
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BACKGROUND
All publications mentioned herein are cited for the purpose of familiarizing the reader with the background of the invention. Nothing herein is to be construed as an admission that these references are prior art in relation to the inventions described herein.
Although Type 2 Diabetes
Organic compounds
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This application is the National Stage of Application No. PCT/US07/64974 filed Mar. 27, 2007, which claims benefit under 35 U.S.C. .sctn.119(e) of U.S. Provisional Application No. 60/787,104, filed Mar. 29, 2006, the contents of which are incorporated herein by reference in their entirety.
The
Pyrazolopyridine compound and processes for preparation thereof
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The present invention relates to novel pyrazolopyridine compound and a pharmaceutically acceptable salt thereof.
More particularly, it relates to novel pyrazolopyridine compound and a pharmaceutically acceptable salt thereof, which are adenosine antagonists and possess various pharmaceutical actions
Organic compounds
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The present invention relates to novel imidazole derivatives that are used as aldosterone synthase inhibitors, as well as for treatment of a disorder or disease mediated by aldosterone synthase (CYP11B2) and/or 11-beta-hydroxylase (CYP11B1).
The present invention provides a compound of formula
Regulation of metabolism by miR-378
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DESCRIPTION OF THE TEXT FILE SUBMITTED ELECTRONICALLY
The contents of the text file submitted electronically herewith are incorporated herein by reference in their entirety: A computer readable format copy of the Sequence Listing (filename: MIRG.sub.--022.sub.--01WO_SeqList_ST25.txt, date recorded:
Organic compounds
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The present invention relates to novel imidazole derivatives that are used as aldosterone synthase and aromatase inhibitors, as well as for treatment of a disorder or disease mediated by aldosterone synthase or aromatase.
The present invention provides a compound of formula (I)
##STR00002## wherein
Organic compounds
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The present invention relates to novel imidazole derivatives that are used as aldosterone synthase and aromatase inhibitors, as well as for treatment of a disorder or disease mediated by aldosterone synthase or aromatase.
The present invention provides a compound of formula (I)
##STR00002## wherein
Organic compounds
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The present invention relates to novel imidazole derivatives that are used as aldosterone synthase and aromatase inhibitors, as well as for treatment of a disorder or disease mediated by aldosterone synthase or aromatase.
The present invention provides a compound of formula (I)
##STR00002## wherein
Composition comprising protein material and compounds comprising non-oxidizable fatty acid entities
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FIELD OF INVENTION
The use of a combination of non .beta.-oxidizable fatty acid entities and a protein material has shown surprising synergistic effects. The present invention concerns a composition prepared from a combination of compounds comprising non .beta.-oxidizable fatty acid entities and a
Cardioprotective phosphonates and malonates
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FIELD OF THE INVENTION
This invention relates to pyridoxine phosphonate analogues, to pyridoxine malonate analogues, to their preparation, to pharmaceutical compositions thereof, and to treatments for cardiovascular and related diseases, for example, hypertrophy, hypertension, congestive heart
Indolylmaleimide derivatives
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The present invention relates to indolylmaleimide derivatives, process for their production and pharmaceutical compositions containing them.
More particularly the present invention provides a compound of formula I
##STR00002## wherein R.sub.a is H; CH.sub.3; CH.sub.2--CH.sub.3; or isopropyl, R.sub.b
Indolylmaleimide derivatives
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The present invention relates to indolylmaleimide derivatives, process for their production and pharmaceutical compositions containing them.
More particularly the present invention provides a compound of formula I
##STR00002## wherein
R.sub.a is H; CH.sub.3; CH.sub.2--CH.sub.3; or isopropyl,
R.sub.b
Combination of metabolic bio-energetic and nutra-epigentic regulators, nutraceutical compounds in conventional and nanotechnologies combination to revert and prevent the chronic damage accelerated cellular senescence produced by diabetes and other degenerative chronic complex diseases
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TECHNICAL FIELD
The present invention focuses on definition of pharmaceutical compositions and proposed method for the treatment of metabolic syndrome, diabetes mellitus and aging. Compounds and compositions of natural origin are disclosed in the description. More particularly, this invention
Polynucleotides that encode the calcitonin gene-related peptide receptor coponent factor (HOUNDC44)
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FIELD OF THE INVENTION
This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists
Fibronectin based scaffold domain proteins that bind to myostatin
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FIELD OF THE INVENTION
The present invention relates to fibronectin-based scaffold domain proteins that bind myostatin. The invention also relates to the use of the innovative proteins in therapeutic applications to treat muscle-wasting diseases and metabolic disorders. The invention further relates
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