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isoflavone/majs
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Estrogen receptor α and β expressions in hypothalamus-pituitary-ovary axis in rats exposed lactationally to soy isoflavones and bisphenol A.
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OBJECTIVE
This paper aims to investigate the uterotrophic activities of lactational exposure to combination of soy isoflavones (SIF) and bisphenol A (BPA) and to examine estrogen receptor α (ERα) and estrogen receptor β (ERβ) expressions in hypothalamus-pituitary-ovary axis and
Early life exposure to isoflavones adversely affects reproductive health in first but not second generation female CD-1 mice.
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Soy-based infant formula (SBIF) can be a substantial source of soy isoflavones during early life. Because soy isoflavones have the capacity to mimic endogenous estrogen and thereby exert hormone-like effects, there is concern regarding reproductive health. The objectives were to determine if
[Effects of soy isoflavone on the reproductive system development and ER-beta expression in male rat offspring in different postnatal periods].
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OBJECTIVE
To investigate the effects of pre- and post-natal exposure to soy isoflavones (SIF) on the related indicators of the reproductive system development and ER-beta expression in male rat offspring.
METHODS
Pregnant SD rats were randomly divided into a corn oil group (control), 3 SIF groups
Neonatal administration of isoflavones attenuates deterioration of bone tissue in female but not male mice.
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Neonatal exposure to soy isoflavones at levels similar to that of infants fed soy protein formula resulted in higher bone mineral density (BMD), improved bone structure, and greater bone strength at young adulthood in female CD-1 mice (1,2). Our objective in this study was to determine whether these
Bone-specific gene expression patterns and whole bone tissue of female mice are programmed by early life exposure to soy isoflavones and folic acid.
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Female mice exposed to soy isoflavones (ISO) during early postnatal life have improved bone outcomes at adulthood. Since long-lasting effects may be mediated by DNA methylation, we hypothesized that providing supplemental folic acid (FA), a methyl donor, during early life, would enhance the positive
Isoflavone exposure throughout suckling results in improved adult bone health in mice.
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Exposure to isoflavones (ISO), abundant in soy protein infant formula, for the first 5 days of life results in higher bone mineral density (BMD), greater trabecular connectivity and higher peak load of lumbar vertebrae (LV) at adulthood. The effect of lengthening the duration of exposure to ISO on
Adequate but not supplemental folic acid combined with soy isoflavones during early life improves bone health at adulthood in male mice.
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Previous investigations from our laboratory have demonstrated that neonatal exposure to soy isoflavones (ISO) improves bone outcomes in CD-1 mice at adulthood with greater benefits in females than males. This study determined whether early-life exposure to supplemental folic acid (FA) - that may
The influence of dietary isoflavone on the uterotrophic response in juvenile rats.
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Current in vivo methods to identify and assess reproductive hazards of endocrine disrupting substances are often confounded by the presence of isoflavones (genistein, diadzein, glycitein), strongly hormonally-active substances, in the diet of laboratory rodents. However, studies that have attempted
Pharmacokinetics of ipriflavone and metabolites after oral administration of a corn-oil suspension relative to the Osteofix tablet.
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Ipriflavone (IP) is a derivative of naturally occurring isoflavones and is marketed as Osteofix for the treatment of osteoporosis in Europe. IP has poor aqueous solubility, and the Osteofix compressed tablet has poor and variable bioavailability (F ). IP is incompletely absorbed after oral
Beta-glucosidase isolated from soybean okara shows specificity toward glucosyl isoflavones.
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A novel beta-glucosidase was isolated from soybean okara in this study. Along with the beta-glucosidase, a considerable basic 7S globulin of soybean was obtained in the initial extraction products. The protein samples pretreated with 130 mM dithiothreitol before the step of CM-Sepharose
Isoflavone profiles and antioxidant properties in different parts of soybean sprout.
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Sprouting is one of the processing methods to enhance bioavailability of some nutrients of agricultural products. Soybeans were germinated for 6 days and soybean (SB), soybean sprout (SBS), cotyledon of soybean sprout (CSS), and hypocotyl and root of soybean sprout (HRSS) were collected. Isoflavone
Soy isoflavones attenuate oxidative stress and improve parameters related to aging and Alzheimer's disease in C57BL/6J mice treated with D-galactose.
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d-galactose (DG)-induced aging in C57BL/6J (B6) mice (3-4 mo) was used to examine the effects of soy isoflavones (SIF). Mice were divided into six groups: corn oil control, DG treatment, DG+melatonin (1 mg/kg BW), and DG+low (0.1 mg/kg), median (0.5 mg/kg) or high (2.5 mg/kg) SIF. DG was
Production of the isoflavones genistein and daidzein in non-legume dicot and monocot tissues.
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Metabolic engineering for production of isoflavones in non-legume plants may provide the health benefits of these phytoestrogens from consumption of more widely used grains. In legumes, isoflavones function in both the symbiotic relationship with rhizobial bacteria and the plant defense response.
Effect of biochanin A on corn grain (Zea mays) fermentation by bovine rumen amylolytic bacteria.
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OBJECTIVE
The objective was to determine the effect of biochanin A (BCA), an isoflavone produced by red clover (Trifolium pratense L.), on corn fermentation by rumen micro-organisms.
RESULTS
When bovine rumen bacterial cell suspensions (n = 3) were incubated (24 h, 39°C) with ground corn, amylolytic
In silico analysis of antidiabetic potential of phenolic compounds from blue corn (Zea mays L.) and black bean (Phaseolus vulgaris L.).
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The growing interest in bioactive compounds, especially in polyphenols, is due to their abundance in the human diet and potentially positive effects on health. The consumption of polyphenols has been shown to possess anti-diabetic properties by preventing insulin resistance or insulin secretion
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