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Side 1 fra 38 resultater
Pathogenesis of Acanthamoeba keratitis: carbohydrate-mediated host-parasite interactions.
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Acanthamoeba keratitis is a sight-threatening corneal infection. In a recent study, the saccharide mannose has been shown to inhibit the binding of Acanthamoeba organisms to the epithelium of the cornea (L. D. Morton, G. L. McLaughlin, and H. E. Whiteley, Infect. Immun. 59:3819-3822, 1991). In an
Evaluation of therapeutic interventions for vaccinia virus keratitis.
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BACKGROUND
Vaccinia virus keratitis (VACVK) is a complication of smallpox vaccination that can result in blindness. There are no Food and Drug Administration-approved treatments for VACVK, and vaccinia immunoglobulin (VIG) is contraindicated in isolated VACVK. We used a rabbit model of infection to
Staphylolysin is an effective therapeutic agent for Staphylococcus aureus experimental keratitis.
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BACKGROUND
Therapy of S. aureus keratitis is increasingly challenging due to emerging resistant strains. Staphylolysin (LasA protease) is a staphylolytic endopeptidase secreted by Pseudomonas aeruginosa. The purpose of the current study was to study the effect of treatment with staphylolysin on
Modulation of immunogenic keratitis in rabbits by topical administration of inhibitors of lipoxygenase and cyclooxygenase.
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Intrastromal injection with human serum albumin (HSA) in the rabbit cornea induced edema and a ring-shaped leukocyte infiltrate followed by neovascularization. The effect of topically administered lipoxygenase and cyclooxygenase inhibitors on this inflammatory keratitis was studied. The lipoxygenase
Combination therapy for dendritic keratitis with human leukocyte interferon and acyclovir.
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We treated 45 patients with virologically verified dendritic keratitis with a combination of interferon and acyclovir 3% or with placebo and acyclovir 3% in a double-masked study. One drop of human leukocyte interferon (30 X 10(6) IU/ml) or albumin-placebo was administered daily. Acyclovir ointment
Combination therapy for dendritic keratitis with acyclovir and alpha-interferon.
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Fifty-nine patients with superficial herpetic keratitis were treated with 3% acyclovir ointment five times a day in combination with alpha-interferon (30 million IU/mL) or albumin-placebo once a day in a stratified double-masked clinical trial. All patients had minimal wiping of the superficial
Modulation of immunogenic keratitis in rabbits by topical administration of poly-unsaturated fatty acids.
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Several unsaturated fatty acids are precursors of prostaglandins and leukotrienes. Depending on their precursor, these prostaglandins and leukotrienes have different biological characteristics. The effects of topically administered fatty acids on an experimentally provoked inflammatory keratitis
Recurrent immunogenic interstitial keratitis. Production in the guinea pig by extraocular means.
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Combinations of intracutaneous (IC) and intravenous (IV) injections of bovine gamma-globulin (BGG) or bovine serum albumin (BSA) induced interstitial keratitis in 24 of 29 guinea pigs. For IC injection, antigen was incorporated in complete Freund adjuvant. When IC and IV BGG reactants were
Modulation of bacterial adhesion to hydrogel contact lenses by albumin.
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OBJECTIVE
The purpose of this investigation was to measure the abilities of Pseudomonas aeruginosa and Staphylococcus epidermidis strains to adhere to two hydrogel lens materials and measure the effect of a protein-coated surface on the number of adhered bacteria.
METHODS
Proteins absorbed to
Keratotomy model of pseudomonas keratitis: gentamicin chemotherapy.
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BACKGROUND
Chemotherapy of bacterial keratitis requires frequent application of antibiotic drops. Collagen shields containing antibiotics could reduce the need for frequent antibiotic application. To determine the effect of gentamicin-containing collagen shields and gentamicin drops on Pseudomonas
Tear stix tests for leucocyte-esterase, nitrite, haemoglobin, and albumin in normals and in a clinical series.
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Tears are absorbed by a tuft of cotton and subjected to stix test for leucocyte-esterase (L), nitrite (N), haemoglobin (H), and albumin (A). Testing of 84 cases of infectious conjunctivitis and 282 normals revealed nosographic sensitivity to L in 89% and a specificity of 98%. By including N (only
The influence of a fish oil dietary supplement on immunogenic keratitis.
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Fish lipids contain large amounts of eicosapentaenoic acid (EPA) and docosahexaenoic acid. These fatty acids are known to have an influence on prostaglandin (PG) and leukotriene (LT) synthesis. We studied the effect of a fish oil dietary supplement on an immune-complex-induced keratitis of the
Comparative analysis of the tear protein profile in mycotic keratitis patients.
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OBJECTIVE
Mycotic keratitis is a major cause of corneal blindness in India. A proper understanding of the pathogenesis may help in refining the existing treatment. The purpose of this study is to examine the total tear protein profile of fungal keratitis patients, which may have a bearing on
Quantitative profiling of tear proteome reveals down regulation of zinc alpha-2 glycoprotein in Aspergillus flavus keratitis patients.
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Corneal mycotic ulceration is predominantly due to Aspergillus and Fusarium solani infection in tropical countries. In this study, we examined the proteome profile of tear samples from A. flavus keratitis patients at various stages of infection. The proteome was profiled using 2D PAGE and the
In vivo effect of bevacizumab-loaded albumin nanoparticles in the treatment of corneal neovascularization.
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Corneal neovascularization (CNV) is associated with different ocular pathologies, including infectious keratitis, trachoma or corneal trauma. Pharmacological treatments based on the topical application of anti-VEGF therapies have been shown to be effective in the treatment and prevention of CNV. The
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