kidney neoplasms/nikotin

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Nanog mediates tobacco smoke-induced enhancement of renal cancer stem cell properties

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Nanog plays an important role in the regulation of cancer stem cells (CSCs) which participate in tumorgenesis and progression. In renal cancer, tobacco smoke (TS) is considered a major risk factor. However, the molecular mechanism by which TS induces the development of renal CSC properties remains

Nicotine induces alteration of H3K27 demethylase UTX in kidney cancer cell.

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Cigarette smoking is one of the most important risk factors for kidney cancer, but the molecular mechanism is poorly understood. To examine the expression change of histone H3 on lysine 27 trimethylase (H3K27me3) demethylases ubiquitously transcribed TPR gene on the X chromosome (UTX) in kidney

Tobacco smoking, body mass index, hypertension, and kidney cancer risk in central and eastern Europe.

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In a case-control study of kidney cancer in four central European countries, with 1097 incident cases and 1476 controls, we found an increased risk for self-reported hypertension and for obesity. Additional unknown risk factors are likely to be responsible for the high rates of kidney cancer in this

Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study.

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CHEK2 is a key cell cycle control gene encoding a pluripotent kinase that can cause arrest or apoptosis in response to unrepaired DNA damage. We report a large case-control study of a non-functional variant that had previously been expected to increase cancer rates. Four thousand and fifteen cancer

Nicotine-induced oxidative stress contributes to EMT and stemness during neoplastic transformation through epigenetic modifications in human kidney epithelial cells.

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Nicotine is a component of cigarette smoke and mounting evidence suggests toxicity and carcinogenicity of tobacco smoke in kidney. Carcinogenicity of nicotine itself in kidney and the underlying molecular mechanisms are not well-understood. Hence, the objective of this study was to determine the

Systematic review of the relation between smokeless tobacco and cancer in Europe and North America.

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BACKGROUND Interest is rising in smokeless tobacco as a safer alternative to smoking, but published reviews on smokeless tobacco and cancer are limited. We review North American and European studies and compare effects of smokeless tobacco and smoking. METHODS We obtained papers from MEDLINE

Gender- and race-specific comparison of tobacco-associated cancer incidence trends in Florida with SEER regional cancer incidence data.

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OBJECTIVE Analysis of state and national tobacco-associated cancer trends is critical for the identification of high-risk regions of the country that require the attention of the public health community. This study compares Florida race- and gender-specific cancer trends with pooled data obtained

A population-based study on the association between urinary calculi and kidney cancer.

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BACKGROUND Using a nationwide population-based dataset and case-control study design, we investigate the association between urinary calculi (UC) and kidney cancer (KC) in Taiwan. METHODS The data for this case-control study were sourced from the Taiwan National Health Insurance program. The cases

Family history and the risk of kidney cancer: a multicenter case-control study in Central Europe.

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An elevated familial relative risk may indicate either an important genetic component in etiology or shared environmental exposures within the family. Incidence rates of kidney cancer are particularly high in Central Europe, although no data were available on the familial aggregation or genetic

Smoking-adjusted risk of kidney cancer by occupation: a population-based cohort study of Nordic men.

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Background: Evidence suggests that among some occupational groups, there is an elevated risk of kidney cancer. This might, however, derive from a difference in smoking habits across occupational groups. The objective of this study was to determine smoking-adjusted occupational variation in

War on Carcinogens: industry disputes human relevance of chemicals causing cancer in laboratory animals based on unproven hypotheses, using kidney tumors as an example.

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Evidence from studies in animals is essential for identifying chemicals likely to cause or contribute to many diseases in humans, including cancers. Yet, to avoid or delay the implementation of protective public health standards, the chemical industry typically denies cancer causation by agents they

[Epidemiology and detection of renal cancer in adults].

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The incidence of renal carcinoma in France is 7 for 100,000 men and 3 for 100,000 women. Most cases are found in patients in their sixties or seventies. With the exception of the rare Von Hippel-Lindau disease, the only risk factor is tobacco smoking. The circumstances in which renal carcinoma is

Declining mortality from kidney cancer in Europe.

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Mortality rates from kidney cancer increased throughout Europe up until the late 1980s or early 1990s. Trends in western European countries, the European Union (EU) and selected central and eastern European countries have been updated using official death certification data for kidney cancer

Epidemiology of kidney cancer.

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Renal-cell carcinoma usually affects those over 40 years old, and, in any age group, the disease occurs about twice as frequently among men as it does among women. The incidence of the disease has been steadily increasing over the years. In the United States, the probability of surviving after

[Sporadic kidney cancer of young subjects: Study of the clinical and pathological features of a bicentric cohort].

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BACKGROUND The epidemiology of kidney cancer is evolving with a net increase in the incidence of renal tumors, globally, and in young people in particular. OBJECTIVE To evaluate the incidence and clinical and pathological characteristics of sporadic renal tumors in young subjects and their risk

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