muscular atrophy/betændelse

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New Imaging Biomarkers for Muscular Diseases - Multispectral Optoacoustic Imaging in Spinal Muscular Atrophy

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SMA is an autosomal-recessive disorder, characterized by progressive muscle weakness and atrophy with an incidence of 1/10,000. The condition is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1), resulting in reduced expression of the survival motor neuron (SMN)

Phrenic Nerve Block to Mitigate Self-inflicted Lung Injury

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The use of protective mechanical ventilation has improved prognosis on patients with Acute Respiratory Failure. The association of neuromuscular blockade in the first 48-72h has additionally contributed to a higher survival rate. Such improvement may be due to the reduction of transpulmonary

Paracetamol Study in Patients With Low Muscle Mass

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1. Aim 1. Objectives Primary objective: The aim of the project is to study the pharmacokinetics of therapeutic doses of paracetamol with specific emphasis on the contributions of the metabolites (glucuronide, sulphate, cysteine and mercapturate), in patients with spinal muscular atrophy(SMA),

Comparison Between Subacromial Infiltrations

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Shoulder pain is a common complaint in patients of all ages and activity levels, it is estimated that approximately 50% of the general population will experience at least one episode of shoulder pain over the course of a year. Shoulder pain has a general prevalence of 6.9-34%. The shoulder is the

Omega 3 Fatty Acid Treatment for Pediatric Musculoskeletal Health

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Medical treatments and disease pathophysiology can result in prolonged immobilization that places hospitalized infants and children at risk for serious musculoskeletal complications including bone loss, fragility fractures, and muscle atrophy. Patients at the highest risk for inpatient fracture

Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract

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Malnutrition is characterized by a negative energy balance due to a deep skeletal muscular loss, which is itself secondary to the reduction of intake and metabolic abnormalities aggravating the loss of weight. Sarcopenia is defined as the loss of muscle mass, the consequences of which are a decrease

Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia

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Reflex Sympathetic Dystrophy (RSD), Complex Regional Pain Syndrome (CRPS), Causalgia, and Fibromyalgia represent progressive systemic pain conditions which often worsen over time. They appear to be dysregulation of the central nervous system (CNS) and the autonomic system

Stepper Aerobic Training on Fitness, Disability, Inflammation and Thrombosis in Stroke Patients

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In Taiwan, there are 220,00 stroke survivors and each year, 10,000 new suffers causing impairment in daily activities. This is the leading cause of disability and consumes 4.5 billions of National Health Insurance yearly. More than half of them become hemi-paretics and hemi-plegics. Stroke leads to

A Study to Evaluate the Performance of a Diagnostic Test in ALS

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ALS, also known as Lou Gehrig's disease, is a rapidly progressive, degenerative disease of motor neurons in the brain and spinal cord that leads to muscle atrophy and spasticity in limb and bulbar muscles. Clinical presentations of this fatal disease include weakness, loss of ambulation,

Neuroimmunology Branch Repository

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Purpose This protocol has the following goals: 1. To enable prospective IRB review of research using human samples and data collected under other Neuroimmunology Branch (NIB) protocols 2. To enable retrospective review of samples and data from the branch s protocols that have been terminated prior

Exercise For Sub-acute Stroke Patients in Jamaica

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Stroke leads to profound cardiovascular deconditioning and secondary abnormalities in paretic skeletal muscle that worsen cardiovascular health. Conventional rehabilitation focuses on restoration of daily function, without an adequate exercise stimulus to address deconditioning or the muscle

Influence of Muscular Atrophy on Biological and Functional Benefit of Respiratory Rehabilitation in Patients With Chronic Respiratory Failure

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We therefore propose to explore the effect of a rehabilitation program including endurance and resistance exercises on muscle biopsies. The present study should help to know the molecular pathways implicated in muscle atrophy in CRF patients and to assess their evolution with rehabilitation. This

Efficacy Study of FANG(30) for Active Rheumatoid Arthritis in Adult Patients

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Introduction: Rheumatoid Arthritis (RA) is a common rheumatic disease characterized by pain, inflammation and reduction in joint function. Hands and feet are the most commonly affected joints and pain is the cause that brings patients with RA to search for medical assistance. Factors causing pain

Energy Costs of Spasticity in Spinal Cord Injury: A Pilot Investigation

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Obesity is at epidemic proportions in the population with spinal cord injury (SCI), and is likely the mediator of the metabolic syndrome in this special population. Recent literature reviews have suggested that obesity is present in > 67% of persons with SCI. Additionally, recent studies have

Inflammatory Abnormalities in Muscle After Stroke: Effects of Exercise

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Stroke is the leading cause of disability in the United States. Biological changes in hemiparetic skeletal muscle may further propagate the disability. The investigators report gross muscular atrophy and major shift to fast myosin heavy chain (MHC) isoform distribution in hemiparetic thigh that are

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