osteoporosis/feber

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Interest of Denosumab Treatment in Osteoporosis Associated to Systemic Mastocytosis

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Systemic mastocytosis (SM) represents a heterogenous group of disease characterized by abnormal proliferation of mast cells caused by activating mutations in c-Kit receptor; a tyrosine kinase family receptor present in mast cell that control cell proliferation. Prevalence of SM is estimated to 1/20

Denosumab and Male Infertility: a RCT

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INTRODUCTION Infertility is a serious problem estimated to affect 7-26% of all couples globally (1;2). Approximately 9% of all newborns were conceived by assisted reproductive techniques in 2013 in Denmark (Danish Fertility Society). Impaired semen quality is the causal or contributing factor in

Denosumab for the Treatment of Osteoporosis in Children: A Pilot Study

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Bone fractures without significant trauma (also known as osteoporosis) are a frequent complication of chronic childhood diseases (for example, Duchenne muscular dystrophy and inflammatory disorders) and genetic disorders (such as osteogenesis imperfecta). To date, the only effective therapy for the

TNFSF11 Inhibition and Fertility: a Prospective Study

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The receptor activator of NF-kB ligand (RANKL) system is considered important for bone homeostasis . RANKL exist in three isoforms and the effects of all isoforms are mediated through binding to a specific receptor (receptor activator of NF-KB (RANK)). RANKL is predominantly found as a transmembrane

Compression in Anklefracture Treatment, The CAT-study

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Malleolar fractures Surgical treatment of patients with malleolar fractures imposes a special challenge for orthopaedic surgeons. A typical ankle fracture results in haematoma, sometimes blistering and almost always oedema formation. This postpones the optimal time for surgery. When operating on a

Study of the Prevalence and Associated Factors With Hypogonadism in HIV + Men

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Assess the prevalence and clinical, biological, paraclinical and therapeutic factors associated with primary or secondary hypogonadism in HIV treated and virologically suppressed patients.

Delayed Antibiotic Treatment in Community-acquired Pneumococcal Pneumonia.

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In this retrospective cohort study, we plan to include all patients presenting with a community-acquired pneumococcal pneumonia at the University Hospital of Zurich between January 1, 2006 and June 30, 2012 (6½ years). The patients will be identified either with one or more blood culture pairs

Safety and Efficacy of Whole-body Vibration as add-on Treatment of Osteoporosis in Post-menopausal Women

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Objectives Primary 1. To establish the effect of whole-body vibration (WBV) on biomarkers of bone remodelling in postmenopausal women with osteoporosis. 2. To establish the effect of whole-body vibration (WBV) on fall risk and low back pain in postmenopausal women with osteoporosis. Secondary 1. To

Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of ITF2357 on Mucosal Healing in Patients With Moderate-to-severe Active Crohn's Disease

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ITF2357 is an orally active, synthetic inhibitor of histone deacetylase (HDAC) enzyme, which has been demonstrated to selectively inhibit the in-vitro production of pro-inflammatory cytokines and to exhibit in-vivo anti-inflammatory effects, both in animals and in humans. Crohn's Disease (CD) is a

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