Subjects will receive the medication elagolix

Infertility

Endometriosis

Elagolix 200mg twice daily orally for 60 days prior to beginning frozen embryo transfer preparation

Elagolix 200 MG

Leuprolide Acetate intramuscularly every 28 days (twice) prior to beginning frozen embryo transfer preparation

Leuprolide Acetate 3.75 MG/ML

Serum follicle stimulating hormone (FSH), estradiol, luteinizing hormone (LH), progesterone, human chorionic gonadotropin (hCG), serum for microarray analysis, complete blood count, and chemistry panel with liver functions levels will be drawn via blood draw

Lab work

Colorado Center for Reproductive Medicine

Comparison Elagolix vs Depot Leuprolide Prior to Frozen Embryo Transfers in Patients With Endometriosis

The Effect of Elagolix in Comparison to Leuprolide Acetate on in Vitro Fertilization (IVF) Cycle Outcomes After a Transfer of Euploid Embryos to Patients With Surgically Diagnosed Endometriosis: A Pilot Trial

Implantation rates of both groups will be compared (defined as number of intrauterine gestational sacs with visible cardiac activity noted on ultrasound examination performed 2-3 weeks after initial positive pregnancy test)

Comparative biochemical pregnancy rates (positive pregnancy tests with no evidence of intrauterine gestational sac noted at ultrasound performed 2-3 weeks after initial positive pregnancy test) per embryo transfer

FSH, LH, Estradiol, progesterone will compared after 4 weeks and 8 weeks of initiation of treatment

At the end of the pregnancy. Live birth rates and pregnancy loss rates will be compared between the two groups

Eric Surrey, M.D.

Medical Director

AbbVie

Test group will receive Elagolix 60 days prior to initiating frozen embryo transfer preparation.
Control group will receive depot leuprolide twice (once every 28 days) prior to initiation frozen embryo transfer preparation.

This group of patients will receive estradiol patches prior to the IVF cycle.

This group of patients will receive OCP's prior to the IVF cycle.

IVF Poor Responders

Estradiol

Oral Contraceptive Pills (OCP)

Duke Fertility Center

Optimizing Ovulation Induction in the Poor Responder

Optimizing Ovulation Induction in the Poor Responder: a Randomized Clinical Trial of Luteal Phase Estradiol Versus Combined Oral Contraceptive Pill on Ovarian Morphology and Biomarkers Prior to Ovulation Induction

We will measure follicular response and synchrony following adminstration of extradiol patches or oral contraceptive pills.

ovarian cysts/hovedpine

Comparison Elagolix vs Depot Leuprolide Prior to Frozen Embryo Transfers in Patients With Endometriosis

Optimizing Ovulation Induction in the Poor Responder

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