phleum subulatum/rhinitis

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Phleum pratense-specific T cells of allergic rhinitis patients display a broader recognition pattern than phleum pratense-specific serum immunoglobulin E.

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BACKGROUND The role of allergen-specific CD4+ T lymphocytes in the pathophysiology of atopic disease is well established. Previous studies on allergen-specific T-cell responses have focused on the recognition of single major allergens to identify T-cell epitopes. OBJECTIVE However, it is not clear

Oral/sublingual Phleum pretense grass tablet (Grazax/Grastek) to treat allergic rhinitis in the USA.

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With the approval of two grass tablets and one ragweed tablet for sublingual immunotherapy (SLIT) by the US FDA in April 2014, the practice of allergy immunotherapy (AIT) in the USA has dramatically changed. Until this time, there were no approved allergen extracts for sublingual administration and

Allergenic profile to Phleum pratense and immunological changes induced after grass allergen-specific immunotherapy.

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BACKGROUND The introduction of molecular diagnoses has provided evidence of the existence of several different allergenic profiles in grass-sensitised individuals, reflecting the large number of allergens involved. This methodology has become a potent tool for a correct diagnosis and for the

Immunotherapy with a Phleum pratense allergen extract induces an immune response to a grass-mix allergen extract.

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BACKGROUND Grass pollen allergy is one of the most common allergies worldwide, and patients often show sensitization to an array of phylogenetically related species. OBJECTIVE To determine the effect of specific immunotherapy (SIT) with Phleum pratense extract on induction of the immune response to

Intradermal Phleum pratense allergoid immunotherapy. Double-blind, randomised, placebo-controlled trial

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Background: In allergology, the intradermal approach is generally used to establish an etiological diagnosis, with limited experience in specific allergen immunotherapy. Objective:

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever.

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BACKGROUND IgE sensitization against grass pollen is a cause of seasonal allergic rhinitis. OBJECTIVE We sought to investigate the evolution at the molecular level and the preclinical predictive value of IgE responses against grass pollen. METHODS The German Multicentre Allergy Study examined a

Specific Immunotherapy in LAR: a randomized, double-blind placebo controlled trial with Phleum pratense subcutaneous allergen immunotherapy.

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BACKGROUND Allergen immunotherapy has been shown to be an effective treatment for local allergic rhinitis (LAR) to house dust mites. Studies with pollen allergen immunotherapy are limited to observational studies. The aim of this study was to evaluate the clinical efficacy and safety of Phleum

Component-resolved diagnosis for phleum allergy: the role of recombinants.

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BACKGROUND Conventional diagnostic tests (such as radioallergosorbent test [RAST] and skin prick test [SPT]) use native raw pollen allergen extracts to establish allergy. However, recombinant allergens may offer important advantages compared with their natural counterparts. OBJECTIVE This study

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