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Side 1 fra 141 resultater
[Hyperostosis frontalis interna, obesity, polyuria, amenorrhea, arterial hypertension, hyperglycemia, cataleptic attacks, somnolence, Korsakow type of dementia and episodes of acute intracranial hypertension].
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Metabolic abnormalities of the hyperglycemic obese Zucker rat.
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In a cross-sectional study, we evaluated the metabolic profiles of lean (Fa/?) and obese (fa/fa) Zucker male rats at 4 to 8 months of age. Although all of the obese rats (N = 108) demonstrated glucose intolerance, most of the obese rats exhibited only mild elevations of fasted and fed plasma
A new spontaneous animal model of NIDDM without obesity in the musk shrew.
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The EDS (early-onset diabetes in suncus) colony has been developed as a new closed breeding colony of the musk shrew (Suncus murinus, Insectivora) exhibiting a high incidence of spontaneous diabetes mellitus. We investigated the characteristic features of diabetic shrews in this colony. All diabetic
Expression of ICAM-1 on glomeruli is associated with progression of diabetic nephropathy in a genetically obese diabetic rat, Wistar fatty.
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We developed an animal model for non-insulin-dependent diabetes mellitus, a genetically obese rat strain, Wistar fatty. These rats show obesity-related features such as hyperinsulinemia and hyperlipemia, and only males develop diabetic features including hyperglycemia, glucoseuria and polyuria as
Urological Complications of Obesity and Diabetes in Males and Females of Three Mouse Models: Temporal Manifestations.
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Diabetic bladder dysfunction is a frequent complication of diabetes. While many mouse models of diabetes now exist, there has been little systematic effort to characterize them for timing of onset and severity of bladder dysfunction. We monitored metabolic status and tested bladder function by void
Clinical characteristics of type 2 diabetes mellitus in overweight European caucasian adolescents.
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OBJECTIVE
To present the clinical features of Type 2 diabetes mellitus (T2DM) in overweight European Caucasian children and adolescents.
METHODS
We report the clinical characteristics of 16 non-syndromal overweight European Caucasian adolescents with T2DM (10 boys, 6 girls, SDS-BMI in median +2.8,
Altered dipeptidyl peptidase-4 activity during the progression of hyperinsulinemic obesity and islet atrophy in spontaneously late-stage type 2 diabetic rats.
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Altered dipeptidyl peptidase-4 (DPP4) activity during the progression of late-stage type 2 diabetes was measured in Otsuka Long-Evans Tokushima fatty (OLETF) rats. Compared with OLETF rats subjected to 30% food restriction, food-satiated OLETF rats exhibited spontaneous hyperphagic obesity, insulin
Diabetic complications in a new animal model (TSOD mouse) of spontaneous NIDDM with obesity.
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The TSOD mouse has been established as an inbred strain with spontaneous development of diabetes mellitus as the first clinical signs of diabetes. Polydipsia and polyuria are observed at about 2 months old only in male mice, after which hyperglycemia and hyperinsulinemia are detected. Following
Insulin resistance in obesity and its molecular control.
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The Wistar fatty rat is a model of obese non-insulin-dependent diabetes mellitus. Males, but not females, develop hyperglycemia, glucouria and polyuria within 8 weeks of age. The regulation of gene expression by insulin has been shown to be differentially impaired in the liver of the fatty rats. The
Beneficial Effects of Isoflavones in the Kidney of Obese Rats Are Mediated by PPAR-Gamma Expression
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Several studies have demonstrated an important association between altered lipid metabolism and the development of kidney injury because of a high-fat diet. Fructose is also closely associated with renal injury. We opted for a combination of fructose and saturated fats in a diet (DH) that is a model
Simultaneous characterization of metabolic, cardiac, vascular and renal phenotypes of lean and obese SHHF rats.
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Individuals with metabolic syndrome (MetS) are prone to develop heart failure (HF). However, the deleterious effects of MetS on the continuum of events leading to cardiac remodeling and subsequently to HF are not fully understood. This study characterized simultaneously MetS and cardiac, vascular
International trial of long-term dexfenfluramine in obesity.
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In a randomised, placebo-controlled, double-blind study, 822 obese patients of both sexes were given either dexfenfluramine (dF), 15 mg twice daily (404), or placebo (418) in addition to a calorie-restricted diet for 1 year. Patients in both groups lost weight significantly in the first 6 months;
[Childhood obesity as a risk factor for diabetes mellitus type I: the accelerator hypothesis].
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Diabetes mellitus (DM) type I was diagnosed in two children, a girl aged 10.9 years and a boy aged 10.3 years, who suffered from overweight. Both were treated with subcutaneous insulin injections and dietary adjustments. Some of the data in the literature suggest that overweight or obesity during
[International study of the effect of dexfenfluramine in obesity (ISIS): 6 months' results].
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International study of the effect of dexfenfluramine in obesity (ISIS): 6 months results. ISIS is a multicentre therapeutic trial of the "intention to treat" type organized to test the effectiveness and side-effects of dexfenfluramine combined with diet in the treatment of obesity. This was a
Effects of fructose feeding on lipid parameters in obese and lean, diabetic and nondiabetic Zucker rats.
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Effects of fructose feeding in moderate amounts on lipid metabolism of obese versus lean, and diabetic versus nondiabetic Zucker rats, were studied. Forty pairs of male lean and obese animals were assigned to two dietary groups, fructose and glucose. For each diet, one-half of lean and obese animals
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