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potassium/epileptisk anfald
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KCNQ2 and KCNQ3--potassium channel genes which are mutated in benign familial neonatal convulsions (BFNC) and other epilepsies
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BACKGROUND OF THE INVENTION
Epileptic disorders affect about 20 to 40 million people worldwide. Generalized idiopathic epilepsies (IGE) cause 40% of all epileptic disorders and commonly have a genetic basis (Plouin, 1994). Most of the IGEs that are inherited are complex, non-monogenic diseases. One
KCNQ2 and KCNQ3--potassium channel genes which are mutated in benign familial neonatal convulsions (BFNC) and other epilepsies
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BACKGROUND OF THE INVENTION
Epileptic disorders affect about 20 to 40 million people worldwide. Generalized idiopathic epilepsies (IGE) cause 40% of all epileptic disorders and commonly have a genetic basis (Plouin, 1994). Most of the IGEs that are inherited are complex, non-monogenic diseases. One
KCNQ2 potassium channels
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FIELD OF THE INVENTION
The present invention concerns nucleic acids and proteins for potassium channels, as well as related vectors, host cells, processes for preparation, and methods of use. Included within the present invention are methods of screening for compounds that bind to and/or otherwise
1,4 diamino bicyclic retigabine analogues as potassium channel modulators
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FIELD OF THE INVENTION
This invention concerns compounds that modulate potassium channels. The compounds are useful for the treatment and prevention of diseases and disorders which are affected by modulation of potassium ion channels. One such condition is seizure disorders.
BACKGROUND OF THE
Potassium channel activating compounds and methods of use thereof
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FIELD OF THE INVENTION
The present invention relates to compounds and compositions which have been found useful in potassium channel activation, treatment of hypertension, alleviation of the symptoms of addition withdrawal, and all other conditions treatable by a potassium channel opener, and to
Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
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FIELD OF THE INVENTION
This invention concerns novel compounds that activate or otherwise modulate voltage-gated potassium channels. The compounds are useful for the treatment and prevention of diseases and disorders which are affected by modulation of potassium ion channels. One such condition is
Benzyloxy anilide derivatives useful as potassium channel modulators
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FIELD OF THE INVENTION
This invention provides benzyloxy anilide derivatives which activate or otherwise modulate voltage-gated potassium channels. The compounds are useful for the treatment and prevention of diseases and disorders which are affected by modulation of potassium ion channels. One such
Benzyloxy anilide derivatives useful as potassium channel modulators
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FIELD OF THE INVENTION
This invention provides benzyloxy anilide derivatives which activate or otherwise modulate voltage-gated potassium channels. The compounds are useful for the treatment and prevention of diseases and disorders which are affected by modulation of potassium ion channels. One such
DNA encoding rodent KCNQ2 potassium channel
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FIELD OF THE INVENTION
The present invention concerns nucleic acids and proteins for potassium channels, as well as related vectors, host cells, processes for preparation, and methods of use. Included within the present invention are methods of screening for compounds that bind to and/or otherwise
N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-di- methylbutanamide as potassium channel modulators
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FIELD OF THE INVENTION
This invention concerns novel compounds that activate or otherwise modulate voltage-gated potassium channels. The compounds are useful for the treatment and prevention of diseases and disorders which are affected by modulation of potassium ion channels. One such condition is
N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
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FIELD OF THE INVENTION
This invention concerns novel compounds that activate or otherwise modulate voltage-gated potassium channels. The compounds are useful for the treatment and prevention of diseases and disorders which are affected by modulation of potassium ion channels. One such condition is
KCNQ potassium channels and methods of modulating same
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FIELD OF THE INVENTION
The present invention concerns nucleic acids and proteins for potassium channels, as well as related vectors, host cells, processes for preparation, and methods of use. Included within the present invention are methods of screening for compounds that bind to and/or otherwise
KCNQ potassium channels and methods of modulating same
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FIELD OF THE INVENTION
The present invention concerns nucleic acids and proteins for potassium channels, as well as related vectors, host cells, processes for preparation, and methods of use. Included within the present invention are methods of screening for compounds that bind to and/or otherwise
Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
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FIELD OF THE INVENTION
The invention concerns novel compounds that modulate potassium ion channels. The compounds are useful for the treatment and prevention of diseases and disorders which are affected by regulation of potassium ion channels. One such malady is seizure disorders.
BACKGROUND OF THE
Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and -2,3-dihydro-1H-indenes as potassium channel modulators
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FIELD OF THE INVENTION
The invention concerns novel compounds that modulate potassium ion channels. The compounds are useful for the treatment and prevention of diseases and disorders which are affected by regulation of potassium ion channels. One such malady is seizure disorders.
BACKGROUND OF THE
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