proteinuria/hypoxia

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Hypoxia is not the primary mechanism contributing to exercise-induced proteinuria.

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Proteinuria increases at altitude and with exercise, potentially as a result of hypoxia. Using urinary alpha-1 acid glycoprotein (α1-AGP) levels as a sensitive marker of proteinuria, we examined the impact of relative hypoxia due to high altitude and blood pressure-lowering medication

Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia.

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The question of why chronic renal diseases progress is a topic only recently investigated. Putative causes such as proteinuria do not account for all aspects of progressive renal disease. An alternative mechanism, chronic hypoxia, is proposed that might better explain certain elements of progressive

Deletion of Uncoupling Protein-2 reduces renal mitochondrial leak respiration, intrarenal hypoxia and proteinuria in a mouse model of type 1 diabetes.

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OBJECTIVE Uncoupling protein-2 (UCP-2) can induce mitochondrial uncoupling in the diabetic kidney. Although mitochondrial uncoupling reduces oxidative stress originating from the mitochondria and can be regarded as a protective mechanism, the increased oxygen consumption occurring secondarily to

Hypoxia induces ZEB2 in podocytes: Implications in the pathogenesis of proteinuria.

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The glomerular filtration barrier (GFB) plays a critical role in ensuing protein free urine. The integrity of the GFB is compromised during hypoxia that prevails during extreme physiological conditions. However, the mechanism by which glomerular permselectivity is compromised during hypoxia remains

Hypoxia in renal disease with proteinuria and/or glomerular hypertension.

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Despite the increasing need to identify and quantify tissue oxygenation at the cellular level, relatively few methods have been available. In this study, we developed a new hypoxia-responsive reporter vector using a hypoxia-responsive element of the 5' vascular endothelial growth factor untranslated

Tubular proteinuria after perinatal hypoxia.

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Urinary total protein (UTP) and urinary protein pattern have been studied in 23 newborn infants with Apgar scores less than or equal to 3 at one minute or acidosis (pH less than or equal to 7.15) on the first day. On the first and second day UTP excretion was increased in 13 out of 18 patients. At

Effect of continuous positive airway pressure on proteinuria in obstructive sleep apnea.

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Obstructive sleep apnea (OSA) is common in patients with renal disease, and an association between OSA and proteinuria has been proposed. However, the effect on proteinuria of OSA treatment with continuous positive airway pressure (CPAP) is unknown. We experienced a case of severe OSA, where

Hyperlipidaemia, lack of sleep and smoking as risk factors for proteinuria among high altitude mountain trekkers.

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OBJECTIVE The number of alpine accidents has been increasing among trekkers in Japan. Some of the alpine accidents have been related to acute mountain sickness (AMS). At present, the mechanism of AMS is poorly clarified, however, it is well known that hypoxia at high altitudes plays an important

Proteinuria in patients with sleep apnea.

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BACKGROUND Proteinuria severe enough to be in the nephrotic range has been noted on occasion in patients with obstructive sleep apnea (OSA), but it is not known what factors are related to the severity of proteinuria in these patients. This study was conducted to determine if the severity of

Maternal hypoxia developmentally programs low podocyte endowment in male, but not female offspring.

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Fetal hypoxia is a common complication of pregnancy. We have previously reported that maternal hypoxia in late gestation in mice gives rise to male offspring with reduced nephron number, while females have normal nephron number. Male offspring later develop proteinuria and renal pathology, including

[Significance of determination of medium weight molecules in urine in normal pregnancy, in complicated pregnancy and in newborns with hypoxia].

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Women with normal gestation and with gestosis and diabetes and newborns exposed to chronic intrauterine hypoxia were examined in order to elucidate the diagnostic value of measuring the content of low- and medium-weight molecules (MWM) in the urine in some obstetrical and gynecological

Urinary hypoxia-inducible factor-1alpha levels are associated with histologic chronicity changes and renal function in patients with lupus nephritis.

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OBJECTIVE Tubulointerstitial hypoxia in the kidney is considered a hallmark of injury and a mediator of the progression of tubulointerstitial fibrosis. Hypoxia-inducible factor-1alpha (HIF-1alpha), a master transcription factor in cellular adaptation to hypoxia, regulates a wide variety of genes,

Nocturnal hypoxia is associated with silent cerebrovascular disease in a high-risk Japanese community-dwelling population.

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BACKGROUND Sleep-disordered breathing (SDB) is recognized as a risk factor for cerebrovascular disease. The objective of this study was to investigate the relationship between nocturnal hypoxia and silent cerebral infarct (SCI) in the general population. METHODS In the 2001 annual health check in

Proteinuria is associated with sleep apnea in chronic kidney disease.

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The prevalence and severity of sleep apnea (SA) in the chronic kidney disease (CKD) population is not well characterized. Recent studies have yielded highly variable prevalence rates due to cohort heterogeneity and interstudy inconsistencies in defining SA. This study sought to determine the

Effect of submaximal aerobic exercise in hypoxic conditions on proteinuria and hematuria in physically trained young men.

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BACKGROUND Exercise-induced proteinuria is predominantly caused by alterations in renal hemodynamics. The present study was conducted to determine the effect of aerobic exercise in hypoxia on proteinuria and hematuria. METHODS The study population consisted of 17 physically trained healthy young

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