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pycnogenol/kræft
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Pycnogenol reduces talc-induced neoplastic transformation in human ovarian cell cultures.
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Talc and poor diet have been suggested to increase the risk of developing ovarian cancer; which can be reduced by a diet rich in fruit and vegetables. Talc is ubiquitous despite concern about its safety, role as a possible carcinogen and known ability to cause irritation and inflammation. It was
An In Vitro Study on the Interactions of Pycnogenol ® with Cisplatin in Human Cervical Cancer Cells
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Objectives: In the treatment of cancer, it is intended to increase the anticancer effect and decrease cytotoxicity using various plant-derived phenolic compounds with chemotherapeutic drugs. Pycnogenol® (PYC), a phenolic
An evaluation of Vitamin E and Pycnogenol in children suffering from oral mucositis during cancer chemotherapy.
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OBJECTIVE
The purpose of the present study was to evaluate and compare the effectiveness of Vitamin E (E) and Pycnogenol (P) in treatment of Chemotherapy-Related Oral Mucositis (ChROM) in children.
METHODS
A total of 72 children, aged between 6 and 15 years, with ChROM were selected and randomly
Pycnogenol® (extract of French maritime pine bark) for the treatment of chronic disorders.
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BACKGROUND
Oxidative stress has been implicated in the development of a number of conditions including cancer, arthritic disorders and cardiovascular disease. Pycnogenol(®), a herbal dietary supplement derived from French maritime pine bark extract, is standardised to contain 70% procyanidin which
Pycnogenol inhibits immunoglobulin E-mediated allergic response in mast cells.
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IgE-dependent mast cell activation is known to be associated with the allergic diseases. Pycnogenol (PYC) is a standardized extract of the bark of French maritime pine containing bioflavonoids with a potent antioxidant activity. The antiallergic activity of PYC was evaluated using both in vivo and
Pycnogenol(®) for the treatment of chronic disorders.
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BACKGROUND
Oxidative stress has been implicated in the development of a number of conditions including cancer, arthritic disorders and cardiovascular disease. Pycnogenol(®), a herbal dietary supplement derived from French maritime pine bark extract, is standardised to contain 70% procyanidin which
Inhibitory Effect of Pycnogenol® on Airway Inflammation in Ovalbumin-Induced Allergic Rhinitis.
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BACKGROUND
The supplement Pycnogenol® (PYC) has been used for the treatment of several chronic diseases including allergic rhinitis (AR). However, the in vivo effects on allergic inflammation have not been identified to date.
OBJECTIVE
To investigate the treatment results of PYC on allergic
Modulating effects of pycnogenol® on oxidative stress and DNA damage induced by sepsis in rats.
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The aim of this study was to evaluate the protective effects of Pycnogenol® (Pyc), a complex plant extract from the bark of French maritime pine, on oxidative stress parameters (superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities and total glutathione (GSH) and malondialdehyde
Effects of the antioxidant Pycnogenol on cellular redox systems in U1285 human lung carcinoma cells.
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Pycnogenol, which is extracted from the bark of French maritime pine, has been shown to have antioxidant and free radical scavenging activities. Thioredoxin reductase (TrxR), glutathione peroxidase (GPx) and glutathione reductase (GR) are three central redox enzymes that are active in endogenous
Pycnogenol induces differentiation and apoptosis in human promyeloid leukemia HL-60 cells.
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Pycnogenol, rich of many phytochemicals of medical value, is a commercialized nutrient supplement extracted from the bark of European coastal pine. In this study, we investigated the anti-tumor effects of Pycnogenol on HL-60, U937 and K562 human leukemia cell lines. We found that Pycnogenol
Pycnogenol protects against Ionizing radiation as shown in the intestinal mucosa of rats exposed to X-rays.
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X-rays and gamma radiation delivered to the abdominal region for cancer treatment encompasses severe damage to the intestinal mucosa, which significantly impairs a patient's quality of life. To a great extent the deleterious effects of x-radiation originate from radiolysis-induced reactive oxygen
Cancer preventive effect of Morinda citrifolia (Noni).
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Morinda citrifolia (Noni) has been extensively used in folk medicine by Polynesians for over 2,000 years. It has been reported to have broad therapeutic effects, including anticancer activity, in both clinical practice and laboratory animal models. The mechanism for these effects remains unknown.
Pycnogenol may alleviate adverse effects in oncologic treatment.
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OBJECTIVE
A large variety of adverse reactions are well known to frequently occur during chemotherapy and radiotherapy in oncology. Specific medications exist to target individual side effects. The aim of this study was to explore in a pilot trial whether supplementation with French maritime pine
Pro‑apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells.
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Complete surgical resection with clear margins remains the mainstay of therapy for localised fibrosarcomas. Nevertheless, metastatic fibrosarcomas still represent a therapeutic dilemma. Commonly used chemotherapeutic agents like doxorubicin have proven to be effective in <30% of all cases of
Pycnogenol Induces Nuclear Translocation of Apoptosis-inducing Factor and Caspase-independent Apoptosis in MC-3 Human Mucoepidermoid Carcinoma Cell Line.
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BACKGROUND
Pycnogenol is extracted from the pine bark of a tree known as Pinus pinaster that has variety biological effects. However, its anticancer activity has not yet been completely studied. The aim of this study is to investigate anticancer effect of pycnogenol in MC-3 human mucoepidermoid
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