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salicylic acid/slagtilfælde
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Evaluating resistance to acetyl salicylic acid using platelet function test in patients with ischemic stroke at Cipto Mangunkusumo Hospital.
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OBJECTIVE
to identify the prevalence of laboratoric ASA resistance using platelet function tests in patients with ischemic stroke at Cipto Mangunkusumo Hospital and its associated factors.
METHODS
this study was a cross-sectional study involving 50 patients with ischemic stroke who only received ASA
[Acetyl-salicylic acid and trifusal in the prevention of atherothrombotic stroke].
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Simultaneous determination and pharmacokinetics of protein unbound aspirin and salicylic acid in rat blood and brain by microdialysis: an application to herbal-drug interaction.
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Aspirin is commonly used for the prevention of myocardial infarction and ischemic stroke; whereas the Chinese people employ the bu-yang-huan-wu-tang (BYHWT) as a routine herbal formulation for the treatment and prevention of transient ischemic stroke. The current study develops a microdialysis
[Stroke--a study of clinical management and prognosis].
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BACKGROUND
Knowledge on how to treat stroke effectively is increasing, but is not always implemented into clinical practice. The aim of this study was to establish the treatment offered, clinical status at discharge and long-term results for stroke patients admitted to a Norwegian local
Major stroke in a 19-year-old patient with a univentricular heart.
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Patients with univentricular heart malformations are at increased risk of suffering from thromboembolic events. We present a case of a 19-year-old woman born with a univentricular heart who suffered a major stroke while being treated with only salicylic acid. At least 20% of patients with
[Possibilities of primary prevention of stroke: elaboration of a population level strategy].
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This review is devoted to principles of primary prevention of cerebral stroke. Prevalence of stroke and its contribution to development of complications and lethal outcomes is analyzed in detail. Main principles of prevention of stroke are delineated and contemporary international guidelines on
Low stroke rate and few thrombo-embolic events after HeartMate II implantation under mild anticoagulation.
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OBJECTIVE
Bleeding and thrombo-embolism are two of the most threatening adverse events associated with the use of continuous flow left ventricular assist devices (LVADs) in the treatment of severe heart failure. We analysed our LVAD patients treated with the HeartMate II (HM II) device by following
Effect of castration on acetyl salicylic acid metabolism in rabbits.
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OBJECTIVE
The biotransformation of acetyl salicylic acid (ASA) differs within species, and gender differences have been documented and attributed to the effect of sex hormones. Castration remains a standard therapy for men with advanced prostate cancer. We studied the effect of castration on the
Triflusal and aspirin have different effects on inflammatory biomarkers measured in patients with acute ischemic stroke.
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OBJECTIVE
Triflusal is a 4-fluoromethyl derivative of salicylic acid used for secondary prevention of ischemic stroke. Recent experimental data (permanent middle cerebral artery occlusion in rats) have shown a possible role of triflusal in neuroprotection through inhibition of inflammatory
[Aggregation activity of platelets in various periods of ischemic stroke].
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We studied coagulation and vascular-platelet hemostasis in 77 patients at different phases of acute and in early recovery periods of ischemic stroke. All patients had concomitant hypertensive disease and ischemic heart disease. Despite antiaggregant therapy with acetyl salicylic acid hypercoagulable
Detection of free radicals by isolated perfusion of the rat brain following hemorrhagic stroke: a novel approach to cerebrovascular biomarker research.
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Blood-borne biomarkers are a mainstay of diagnosis and follow-up in many diseases. For stroke, however, no reliable biomarkers have thus far been identified. To remedy this situation, we investigated the usefulness of a modified in situ isolated brain perfusion (IBP) technique for screening
Antioxidant effect of acetylsalicylic and salicylic acid in rat brain slices subjected to hypoxia.
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Acetylsalicylic acid (ASA) reduces the incidence of ischemic stroke mainly through its antithrombotic action; however, it also has a direct neuroprotective effect. The present study was designed to evaluate the effect of ASA on oxidative stress and the activity of nitric oxide synthase (NOS) in an
Platelet aggregation and plasma levels of acetylsalicylic acid in stroke patients on long-term treatment with an enteric-coated aspirin formulation.
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Enteric-coated formulations of acetylsalicylic acid (ASA) should be advantageous in prophylaxis after stroke because they cause fewer gastrointestinal side effects. However, the absorption of unchanged ASA and the effectiveness of these formulations have been questioned, which prompted the present
Acetylsalicylic acid provides cerebrovascular protection from oxidant damage in salt-loaded stroke-prone rats.
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Inflammatory processes may play a pivotal role in the pathogenesis of cerebrovascular injury in salt-loaded stroke-prone spontaneously hypertensive rats (SHRSP). Recent reports revealed that acetylsalicylic acid (aspirin) has anti-oxidative properties and elicits nitric oxide release by a direct
Low-dose acetyl salicylic acid versus oral anticoagulation after bioprosthetic aortic valve replacement. Final report of the ACTION registry.
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BACKGROUND
The administration of antiplatelet agents versus anticoagulation after bioprosthetic aortic valve replacement (AVR) remains controversial. This study examined the safety and efficacy of anticoagulation with a vitamin-K antagonist (VKA) versus low-dose acetyl salicylic acid (ASA), up to 6
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