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Nucleolar organizer regions in smooth muscle and breast tumours.
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Paraffin sections of formalin fixed tissues, obtained from patients with smooth muscle and breast tumours, were studied by the silver staining technique to quantitate the Nucleolar Organizer Regions (AgNORs) per nucleus and to assess its significance as an independent variable in predicting the
A smooth-muscle tumor of uncertain malignant potential harboring metastatic breast cancer.
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alpha-Trinositol inhibits FGF-stimulated growth of smooth muscle and breast cancer cells.
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alpha-Trinositol (d-myo-inositol-1,2,6-trisphosphate), an isomer of the intracellular messenger IP(3), has been studied for its anti-inflammatory and other effects in animal experiments and in human. The mechanisms of action remain unknown. Several human pathologies are associated with uncontrolled
TP53 upregulates α‑smooth muscle actin expression in tamoxifen‑resistant breast cancer cells.
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In a previous study, we reported that α‑smooth muscle actin (α‑SMA), one of the mesenchymal marker proteins, is highly expressed in tamoxifen‑resistant breast cancer (TamR) cells. However, the exact mechanism of α‑SMA expression in TamR cells is not fully understood. Here, we investigated the effect
BRCA1 shields vascular smooth muscle cells from oxidative stress.
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BACKGROUND
Excessive production of reactive oxygen species (ROS), in part via upregulation of DNA damage pathways, is a central mechanism governing pathologic activation of vascular smooth muscle cells (VSMCs). We hypothesized that the breast cancer 1, early onset (BRCA1) gene that is involved in
Congenital smooth muscle hamartoma of the nipple: a case report.
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BACKGROUND
Hamartoma is a benign developmental disorder. This focal malformation is composed of mature tissues normally observed in a given organ but randomly distributed, often in disturbed quantitative ratio, with growth rate similar to that of the surrounding tissues. Congenital smooth muscle
Elucidating progesterone effects in breast cancer: cross talk with PDGF signaling pathway in smooth muscle cell.
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Several studies indicate that progesterone exerts relevant effects in breast tissue. However, the exact role of this steroid in breast cancer development and progression has not been elucidated. Here, we show that platelet-derived growth factor (PDGF)-A is one of the progesterone target genes on
[Multiple smooth colon stenosis in 76-year-old female patient].
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Differential diagnostic aspects of colon stenoses are discussed using the example case of a female patient presenting with multilocular colon metastases, who had lobular breast cancer 9 years previously. Typical is linitis plastica, which can indicate tumorous infiltration not only of the stomach,
Docetaxel conjugate nanoparticles that target α-smooth muscle actin-expressing stromal cells suppress breast cancer metastasis.
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Docetaxel-conjugate nanoparticles, known as Cellax, were synthesized by covalently conjugating docetaxel and polyethylene glycol to acetylated carboxymethylcellulose via ester linkages, yielding a polymeric conjugate that self-assembled into 120 nm particles suitable for intravenous administration.
Tamoxifen Accelerates Endothelial Healing by Targeting ERα in Smooth Muscle Cell
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Rationale: Tamoxifen prevents the recurrence of breast cancer and is also beneficial against bone demineralization and arterial diseases. It acts as an Estrogen Receptor (ER) α antagonist in ER-positive breast cancers, whereas it mimics the protective action of 17β-estradiol (E2) in other
Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers.
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Smooth muscle is present in a wide variety of anatomical locations, such as blood vessels, various visceral organs, and hair follicles. Contraction of smooth muscle is central to functions as diverse as peristalsis, urination, respiration, and the maintenance of vascular tone. Despite the varied
Endoscopic ultrasound-guided fine needle aspiration for smooth benign appearing esophageal stricture due to metastatic breast cancer.
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Metastatic breast cancer is an uncommon cause of esophageal stricture. We present an 80 year-old woman with past medical history of locally advanced breast cancer who admitted for evaluation of dysphagia. Barium swallow (i.g. esophageal fluoroscopy) demon-strated moderate irregular narrowing in the
Muscular hamartoma of the breast: a rare breast lesion containing smooth muscle.
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Hamartoma of the breast is an uncommon entity, usually presenting as a well-demarcated breast mass. Microscopically, the lesion is composed of mammary glandular component, fibrous stroma, adipose tissue, and smooth muscle in variable proportions. Among the variants of breast hamartoma, muscular
Up-regulation of transcription of smooth muscle myosin alkali light chain by ethanol in human breast cancer cells.
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Both epidemiological and experimental studies indicate that ethanol is a tumor promoter and that chronic ethanol exposure enhances metastasis of breast cancer cells, and with an in vitro model (T47D human breast cancer cells), we have previously demonstrated that ethanol exposure stimulated the
Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells.
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Numerous clinical therapeutic agents have been identified as DNA damaging. The present study revealed that isoproterenol (Iso) resulted in DNA damage in vascular smooth muscle cells (VSMCs) and increased the levels of intracellular oxygen free radicals. Administration of chlorogenic acid (CGA)
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