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Smooth muscle cell phenotypic switching in stroke.
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Disruption of cerebral blood flow after stroke induces cerebral tissue injury through multiple mechanisms that are not yet fully understood. Smooth muscle cells (SMCs) in blood vessel walls play a key role in cerebral blood flow control. Cerebral ischemia triggers these cells to switch to a
Mechanics of Vascular Smooth Muscle.
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Vascular smooth muscle (VSM; see Table 1 for a list of abbreviations) is a heterogeneous biomaterial comprised of cells and extracellular matrix. By surrounding tubes of endothelial cells, VSM forms a regulated network, the vasculature, through which oxygenated blood supplies specialized organs,
Acute stroke care pathway: Will the journey be smooth?
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Vascular smooth muscle contraction in hypertension.
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Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia, and chronic kidney disease. Pathophysiological mechanisms contributing to the development of hypertension include increased vascular resistance, determined
Subjective scaling of smooth surface friction.
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1. Six men and four women, 30-51 yr of age, were asked to use the tip of the washed and dried index finger to stroke six different featureless, flat surfaces mounted on a three-dimensional force platform. The six surfaces were rosin-coated glass, glass, satin-finished aluminum, poly-vinyl chloride
Arterial smooth muscle cell phenotype in stroke-prone spontaneously hypertensive rats.
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The aim of this study was to determine the phenotype of smooth muscle cells in the arteries of chronically hypertensive animals and to analyze the effects of treatments known to increase the survival of the animal without a clear effect on its hypertensive state. Stroke-prone spontaneously
Epigenetic regulation of smooth muscle cell plasticity.
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Smooth muscle cells (SMC) are the major cell type in blood vessels. Their principal function in the body is to regulate blood flow and pressure through vessel wall contraction and relaxation. Unlike many other mature cell types in the adult body, SMC do not terminally differentiate but retain a
Effective stroke prevention requires timely detection and smooth control of hypertension.
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Bedside evaluation of smooth pursuit eye movements in acute sensory stroke patients.
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OBJECTIVE
Unilateral saccadic pursuit is reported to be suggestive of a pontine lesion in sensory stroke patients. We attempted to verify this eye sign in just-hospitalized pontine sensory stroke patients.
METHODS
Horizontal smooth pursuit eye movements were evaluated upon hospital arrival in 4
[Reactivity of the vascular smooth muscle in stroke-prone spontaneously hypertensive rats].
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Arterial smooth muscle dynamics in development and repair.
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Arterial vasculature distributes blood from early embryonic development and provides a nutrient highway to maintain tissue viability. Atherosclerosis, peripheral artery diseases, stroke and aortic aneurysm represent the most frequent causes of death and are all directly related to abnormalities in
Potassium inhibits cultured vascular smooth muscle cell proliferation.
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Increased dietary K+ increases plasma [K+] and is linked to or associated with reduced mortality from stroke and reduced blood pressure in humans and animals. We hypothesized that physiologic increases in extracellular [K+] ([K]o) directly inhibit cultured vascular smooth muscle cell (VSMC)
RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats.
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RhoA is commonly activated in the aorta in various hypertensive models, indicating that RhoA seems to be a molecular switch in hypertension. The molecular mechanisms for RhoA activation in stroke-prone spontaneously hypertensive rats (SHRSP) were here investigated using cultured aortic smooth muscle
[Reactivity of vascular smooth muscle in stroke-prone spontaneously hypertensive rats (author's transl)].
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Effect of docosahexaenoic acid on smooth muscle cell functions.
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There is increasing evidence that fish oil-enriched diets attenuate the progression of several types of human and experimental renal, intestinal and cardiovascular disorders, including hypertension. Docosahexaenoic acid (DHA), may be one of the active biological component. We previously reported
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