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smooth/triglyceride
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Role of ROCK expression in gallbladder smooth muscle contraction.
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Cholelithiasis is a common medical condition whose incidence rate is increasing yearly, while its pathogenesis has yet to be elucidated. The present study assessed the expression of Rho-kinase (ROCK) in gallbladder smooth muscles and its effect on the contractile function of gallbladder smooth
Increased cellular triglyceride levels in human monocytic and rat smooth muscle cells after lovastatin.
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Beta-hydroxy-beta-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors reduce plasma LDL cholesterol by upregulating hepatic LDL receptors. However, their effects on lipid metabolism in extrahepatic cells may also contribute to their therapeutic benefit. We examined the effects of lovastatin
Triglyceride and cholesteryl ester hydrolysis in a cell culture model of smooth muscle foam cells.
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Cultured rabbit aortic smooth muscle cells were converted to foam cells by exposure to sonicated lipid droplets of defined composition using an inverted culture technique. Uptake of the lipid droplets by the cells was shown to be dependent on the time of exposure to the droplets and on the mass of
Sex mediated lipid metabolism in human aortic smooth muscle cells.
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When human aortic smooth muscle cells in culture were treated with pharmacological doses of estrogen and testosterone for 48 hrs, the rate of cholesterol synthesis measured both by acetate incorporation and the 3, hydroxy 3-methylglutaryl Co enzyme A reductase (HMG-CoA) activity declined
Partial starvation, and "in vitro" contractions of rat uterine smooth muscle. Levels of glycogen and triglycerides.
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The effects of a restricted-diet (50% of the normal intake during 25 days) on the isometric developed tension (IDT) of uterine horns isolated from diestrous non-cycling rats, were explored. After 60 minutes following isolation and mounting the IDT of controls suspended in glucose containing solution
The mitogenic effects of methyl sterculate on aortic smooth muscle cells.
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Cyclopropenoid compounds are derived from naturally occurring C19 long chain fatty acids which have been shown to increase mitosis in rat hepatocytes, to elevate serum cholesterol and to enhance atherosclerosis in hens. In order to study the direct effects of sterculi acid triglyceride on smooth
Stimulation of cholesterol esterification in rhesus monkey arterial smooth muscle cells.
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The influence of homologous high density lipoprotein (HDL) and low density lipoprotein (LDL) and of whole hypercholesterolemic serum on the esterification of oleic acid and cholesterol was studied in rhesus monkey arterial smooth muscle cells. Whole hypercholesterolemic serum and isolated LDL
Apolipoprotein serum amyloid A down-regulates smooth-muscle cell lipid biosynthesis.
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The addition of acute-phase apolipoprotein serum amyloid A (SAA) to cultured aortic smooth-muscle cells caused a decrease in the incorporation of [(14)C]acetate into lipids. Optimal inhibition of lipid biosynthesis was achieved with 2 microM SAA, and the effect was maintained for up to 1 week when
Modulation of DNA synthesis in aortic smooth muscle cells by dinitrotoluenes.
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Studies were conducted to determine if in vivo exposure to dinitrotoluenes (DNT), which is associated with circulatory disorders of atherosclerotic etiology in humans, is associated with alterations of vascular smooth muscle cells (SMC) consistent with the atherogenic process. Sprague-Dawley rats
Vascular smooth muscle cells isolated from adipose triglyceride lipase-deficient mice exhibit distinct phenotype and phenotypic plasticity.
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The alteration of triglyceride (TG) metabolism in vascular smooth muscle cells (SMC) is likely to be correlated with certain phenotype, though this has not been elucidated. Adipose triglyceride lipase (ATGL) exerts major TG catalytic activity in both adipotic and non-adipotic cells. In the present
Low density lipoprotein subfractions and [Ca2+]i in vascular smooth muscle cells.
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Several studies have established that plasma low density lipoprotein (LDL) consists of various discrete subfractions. Using a variety of techniques (analytical ultracentrifugation, equilibrium density gradient ultracentrifugation, and gradient gel electrophoresis), LDL has been fractionated into a
Lipid composition and turnover of rough and smooth microsomal membranes in rat liver.
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Subfractions of rat liver microsomes (rough, smooth I, and smooth II), isolated in a cation-containing sucrose gradient system, were analyzed. After removal of adsorbed and luminal protein, these subfractions had the same phospholipid/protein ratio, about 0.40. Both the classes and the relative
Metabolism of atherogenic lipoproteins by smooth muscle cells of different phenotype in culture.
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Smooth muscle cells of the rabbit aorta, when grown in vitro, express three distinguishable forms of phenotype (contractile, reversible synthetic, and irreversible synthetic). We compared the interactions of these three smooth muscle phenotypes with rabbit very low density lipoprotein (VLDL), low
Different effects of prostaglandins E2 and F2 alpha on triglyceride levels in uterine smooth muscle from diabetic diestrous rats.
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Triglyceride (TG) concentrations in uterine strips isolated from diestrous normal rats, from diestrous streptozotocin (single iv. injection of 65 mg X Kg body weight-1)-diabetic rats and from diestrous diabetic animals, treated in vivo with insulin (protamine zinc insulin 4U X day-1, 6 days, sc.),
The effect of impaired lipid metabolism on the smooth muscle cells of rabbits.
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Our clinical data enabled us to demonstrate a correlation between impaired lipid metabolism and vasculogenic impotent men. Our aim was to evaluate the effect of an impaired lipid metabolism on the smooth muscle of the corpus cavernosum. A total of 16 rabbits were given a cholesterol-enriched diet
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