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Side 1 fra 26 resultater
Stilbene analogs and methods of treating cancer
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TECHNICAL FIELD
The present disclosure is directed to compounds having antineoplastic activity. In particular, the disclosure is directed to halogenated stilbene analogs and methods of identifying the specific molecular target of the stilbene analogs and inhibiting cancer cell growth in a patient by
Stilbene analogs and methods of treating cancer
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Mar. 20, 2012, is named SEQUENCE LISTING.txt and is 5.20 kilo bytes in size.
TECHNICAL
Stilbene derivatives as new cancer therapeutic agents
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to stilbene derivatives that are useful for the treatment of diseases characterized by cell hyperproliferation. For example, the invention provides new stilbene derivatives including water-soluble pro-drug forms of stilbene
Nitrogenated trans-stilbene analogs, method for the obtention and medical applications thereof
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This invention is related to new nitrogenated trans-stilbene analog compounds, more specifically, imine, pyrrol and indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and/or chemoprevention of those mammalian diseases such as
Stilbene like compounds as novel HDAC inhibitors
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FIELD OF THE INVENTION
The present invention relates to novel stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions metabolites and prodrugs thereof. The
Substituted stilbene compounds with vascular damaging activity
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This invention relates to vascular damaging agents and particularly to a series of novel stilbene compounds.
Formation of new vasculature by angiogenesis is a key pathological feature of several diseases (J Folkman, New England Journal of Medicine 333, 1757-1763, 1995). For example, for a solid
Compositions and methods for treating cancer with aberrant lipogenic signaling
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jun. 7, 2013, is named 003252-071731-PCT_SL.txt and is 104,058 bytes in size.
TECHNOLOGICAL
Prevention and treatment of colon cancer
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FIELD OF THE INVENTION
This invention is most closely related to the prevention and treatment of colon cancer.
BACKGROUND
Stilbenes, such as resveratrol and pterostilbene, are a subset of naturally occurring phenolic compounds known to have diverse pharmacological activities including cancer
Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues
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BACKGROUND OF THE INVENTION
The stilbenes isolated from Photorhabdus species bacteria are known to have antibiotic activity (Paul et al. Journal of Chemical Ecology, 7: 589-597 (1981), and Hu et al., Canadian Journal of Microbiology. 44: 1072-1077 (1998). However, these compounds have not been shown
Substituted stilbenes and their reactions
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FIELD OF THE INVENTION
The present invention relates to novel compounds, and more particularly to stilbene and quinone compounds related to combretastatin A-4 and their possible use as anticancer compounds and prodrugs. In further aspects, the present invention relates to the photochemical reactions
Substituted stilbenes and their reactions
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FIELD OF THE INVENTION
The present invention relates to novel compounds, and more particularly to stilbene and quinone compounds related to combretastatin A-4 and their possible use as anticancer compounds and prodrugs. In further aspects, the present invention relates to the photochemical reactions
Stilbene derivatives
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SUMMARY
The stilbene derivatives provided by the present invention are compounds of the general formula: ##STR1## wherein n is an integer of from 1 and 2 and, when n is 1, R.sup.1 and R.sup.2 are individually hydrogen, lower alkoxy or halogen, or, when n is 2, R.sup.1 is hydrogen, lower alkoxy or
Stilbene derivatives
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BACKGROUND OF THE INVENTION
1. Field of the Invention
Some chondrogenetic disorders and dermatological disorders such as psoriasis and malignant disorders such as leukemia can be looked upon as a disease involving a block or an abnormality in differentiation. The present invention relates to novel
Substituted cis- and trans-stilbenes as therapeutic agents
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FIELD OF THE INVENTION
The present invention relates to method(s) of treating a subject afflicted with cancer or a precancerous condition, an inflammatory disease or condition, and/or stroke or other ischemic disease or condition, the method comprising administering to the subject or patient in need
Z-stilbenes derivatives and the pharmaceutical composition thereof
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a Z-stilbenes derivative and a pharmaceutical composition thereof, more particularly, to a Z-stilbenes derivative which can inhibit microtubules polymerization and a pharmaceutical composition thereof.
2.
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