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Side 1 fra 283 resultater
Gyrate atrophy-like phenotype with normal plasma ornithine and low plasma taurine.
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We present the case of a 39-year-old male with sectoral chorioretinal atrophy similar to that seen in gyrate atrophy (GA) but with a normal plasma ornithine level. Unlike previously reported cases of GA, he had below-normal plasma taurine concentration. Much remains unknown about the
Comparison of mRNA expression from Y-chromosome X-degenerate region genes in taurine cattle, yaks and interspecific hybrid bulls.
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The yattle (dzo) is an interspecific hybrid of the taurine cattle (Bos taurus) and the domestic yak (Bos grunniens). F1 hybrid yattle bulls are sterile due to spermatogenic arrest and have misregulation of spermatogenesis genes in the testes. However, the expression pattern of Y
Aspartate-taurine imbalance in dominantly inherited olivopontocerebellar atrophy.
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Amino acids were measured in autopsied brain from two patients who died with a dominantly inherited form of olivopontocerebellar atrophy. Neuropathologic changes found in the brain of these patients suggested a loss of cerebellar climbing fibers. The contents of aspartic acid, gamma-aminobutyric
Taurine treatment of retinal degeneration and cardiomyopathy in a consanguineous family with SLC6A6 taurine transporter deficiency.
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In a consanguineous Pakistani family with two affected individuals, a homozygous variant Gly399Val in the eighth transmembrane domain of the taurine transporter SLC6A6 was identified resulting in a hypomorph transporting capacity of ~15% compared with normal. Three-dimensional modeling of this
Retinal degeneration induced by taurine deficiency in light-deprived cats.
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The effect of light deprivation on the retinal degeneration induced by taurine deficiency in cats was examined in this study. After 25 weeks of taurine-free diet, taurine levels in plasma, retina, heart, cerebellar and cerebral cortex decrease to 16-25% of normal. The ERG a-wave and b-amplitudes
Taurine: the comeback of a neutraceutical in the prevention of retinal degenerations.
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Taurine is the most abundant amino acid in the retina. In the 1970s, it was thought to be involved in retinal diseases with photoreceptor degeneration, because cats on a taurine-free diet presented photoreceptor loss. However, with the exception of its introduction into baby milk and parenteral
Retinal degeneration in cats fed casein. I. Taurine deficiency.
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All cats fed a taurine-free casein diet for at least 23 weeks have shown granularity with a hyper-reflective white zone in the area centralis, nondetectable electroretinograms (ERG's), and structural changes indicating photoreceptor cell degeneration. The present study has demonstrated that cats fed
Synergism between environmental lighting and taurine depletion in causing photoreceptor cell degeneration.
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Experiments were conducted to examine the possible interaction between retinal taurine depletion and environmental lighting in causing photoreceptor cell degeneration. Albino rats were raised from birth in either dim (2 lx) or relatively bright (300 lx) cyclic light. Beginning at weaning, half the
Retinal degeneration relating to taurine deficiency in a cat.
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A 13-year-old spayed Siamese had normal pupillary light reflexes and visual acuity, a dull haircoat , and a history of eating dog food. Binocular indirect ophthalmoscopy of the left fundus revealed an ellipsoid, hyperreflective lesion in the area centralis and a second lesion medial and adjacent to
Age-related retinal degeneration in animal models of aging: possible involvement of taurine deficiency and oxidative stress.
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There is strong evidence that the retina degenerates with age. Electroretinogram deficits and photoreceptor cell death and structural abnormalities have been observed in both animal and human studies of aging. The mechanism behind this phenomenon is a very interesting area for scientific and medical
Taurine Depletion Causes ipRGC Loss and Increases Light-Induced Photoreceptor Degeneration.
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To examine if light exposure exacerbates retinal neuronal loss induced by taurine depletion.
Albino rats received β-alanine in the drinking water to induce taurine depletion. One month later, half of the animals were exposed to white light (3000 lux) continuously for 48 hours and the rest remained
Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments.
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Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice.
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Taurine is involved in cell volume homeostasis, antioxidant defense, protein stabilization, and stress responses. High levels of intracellular taurine are maintained by a Na+-dependent taurine transporter (TAUT) in the plasma membrane. In view of the immunomodulatory and cytoprotective effects of
Taurine ameliorates stress-induced degeneration of the urinary bladder.
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We studied the potential effects of taurine, a free radical scavenger, on chronic water avoidance stress (WAS)-induced degeneration of the mucosa of the urinary bladder in experimental rats. Wistar albino rats were exposed to WAS for 2h/day, for 5 days (WAS group). Before exposing them to WAS,
Muscle proteolytic system modulation through the effect of taurine on mice bearing muscular atrophy.
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Skeletal muscle atrophy occurs in different catabolic conditions and mostly accompanied with upregulation of Muscle ring finger 1 (MuRF1) gene which is one of the master regulatory genes in muscle atrophy. Taurine amino acid is widely distributed in different tissues and has anti-inflammatory and
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