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Lubeluzole blocks increases in extracellular glutamate and taurine in the peri-infarct zone in rats.
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A microdialysis probe was positioned inside the peri-infarct zone of a photochemically induced neocortical infarct in rats. Extracellular glutamate rose within 20 min after the start of infarct induction and continued to increase during the 5 h observation period to 5.5-fold the pre-infarct baseline
Observations on the relationship between the extracellular changes of taurine and glutamate during cortical spreading depression, during ischemia, and within the area surrounding a thrombotic infarct.
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Taurine and glutamate were monitored by microdialysis technique during various cerebral insults: a. Application of K+ triggered a cortical spreading depression (CSD). Taurine and glutamate increased concomitantly but recovery of glutamate was faster than that of taurine. b. Application of NMDA
Protective effect of taurine on myocardial antioxidant status in isoprenaline-induced myocardial infarction in rats.
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We have examined the protective effect of taurine on the myocardial antioxidant defense system in isoprenaline (isoproterenol)-induced myocardial infarction in rats, an animal model of myocardial infarction in man. Levels of diagnostic marker enzymes in plasma, lipid peroxides and reduced
Taurine detected using high-resolution magic angle spinning (1)H nuclear magnetic resonance: A potential indicator of early myocardial infarction.
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Magnetic resonance spectroscopy (MRS) is a unique non-invasive method for detecting cardiac metabolic changes. However, MRS in cardiac diagnosis is limited due to insensitivity and low efficiency. Taurine (Tau) is the most abundant free amino acid in the myocardium. We hypothesized that Tau levels
Elevated blood taurine levels in acute and evolving myocardial infarction.
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Blood samples obtained from 97 consecutive patients admitted to the hospital for chest pain were analyzed for taurine concentrations. The mean value of the maximum taurine concentration in whole blood from AMI patients were greater than the mean value of the maximum taurine concentration in patients
Platelet taurine in patients with arterial hypertension, myocardial failure or infarction.
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The content of taurine in the hypertrophied left ventricle is increased in congestive heart failure an in spontaneously hypertensive (SH) rats. In SH rats the taurine content of and taurine uptake by the platelets are also increased. The present results indicate that, as in the heart, the taurine
Extracellular changes of taurine in the peri-infarct zone: effect of lubeluzole.
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Lubeluzole is a neuroprotective compound that has been shown to stereoselectively rescue sensorimotor function and reduce infarct size in a photochemical stroke model in rats. Tissue swelling, which occurs in the peri-infarct zone, is accompanied by a compensatory taurine release. Therefore, using a
[Effect of the novel taurine derivative on various parameters of metabolism on experimental myocardial infarction].
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The effects of TAU-5, a new N-phenylalkyl derivative of taurine, on the metabolic changes in heart were studied in rats with experimental myocardial infarction. The new drug exhibits a pronounced antiischemic effect related to recovery of the activity of enzymes involved in the energy exchange,
Cerebral Taurine Levels are Associated with Brain Edema and Delayed Cerebral Infarction in Patients with Aneurysmal Subarachnoid Hemorrhage.
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BACKGROUND
Cerebral edema and delayed cerebral infarction (DCI) are common complications after aneurysmal subarachnoid hemorrhage (aSAH) and associated with poor functional outcome. Experimental data suggest that the amino acid taurine is released into the brain extracellular space secondary to
A synergistic protective effect of selenium and taurine against experimentally induced myocardial infarction in rats.
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This study investigated the protective effect of subacute pre-adminsitration of either selenium (Se), taurine (Tau), or both drugs in combination against experimentally induced myocardial infarction (MI) in rats and illustrates the possible mechanisms of action. While solely pre-administration of Se
[The effect of a new phenylalkyl taurine derivative on the size of the necrotic area in experimental myocardial infarct in rats].
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The study of an anti-ischemic action of a new phenilalkyl taurin derivative TAU-60 has discovered that this drug attenuates ECG signs of myocardial infarction and reduces the size of necrosis zone on the anterior wall of the left ventricular myocardium in rats with experimental myocardial
Normalization of heart rate variability with taurine and meldonium complex in post-infarction patients with type 2 diabetes mellitus.
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The purpose of this study is to scrutiny the Dynamics of heart rate variability (HRV) in patients with PICS with 2nd type DM against the background of Taurine (TN) and meldonium (ME). The results of the investigations prove the decrease of the oxidative stress, which is basis of DACN, under the
Elevated blood taurine levels after myocardial infarction of cardiovascular surgery: is there any significance?
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Effect of taurine and coenzyme Q10 in patients with acute myocardial infarction.
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Effects of taurine on cerebral blood flow perfusion, cell apoptosis, and infarct volume in acute cerebral ischemic rats.
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