Patients with primary biliary cirrhosis will be treated with S-adenosyl-L-methionine, tablets 800 mg twice a day (daily dosage 1600 mg) for six months

Primary Biliary Cirrhosis

Patients will be treated with S-adenosyl-L-methionine, tablets 800 mg twice a day (daily dosage 1600 mg) for six months

S-adenosyl-L-methionine

Wunsch

Milkiewicz

Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis

Questionnaire consists 40 questions in 5 domains: Cognition, Itch, Fatigue, Social-Emotional and Other Symptoms, marked with a five-point scale (1=never to 5=always), with higher scores denoting greater symptoms impact and poorer quality of life. The possible range of each domain were: Other Symptoms domain 7-35, Itch 3-15, Fatigue 11-55, Cognitive 6-30, Social and Emotional 13-65 points.

To analyse the influence of SAMe treatment on liver stiffness

To analyse the influence of SAMe treatment on liver function parameters

To analyse the influence of SAMe treatment on 17 bile acids metabolites in serum and urine

Wunsch Ewa

Pomeranian Medical University Szczecin

Laval University

3 sessions per week lasting 30 minutes.
Daily report of bedtime and wake time.
Baseline:
Polysomnography
Actigraphy
Questionnaires
Blood draw
Urine collection
2 weeks:
Questionnaires
Actigraphy download
Sleep log reconciliation
6 weeks:
Polysomnography
Actigraphy download
sleep log reconciliation
Questionnaires
Blood draw
Urine collection

1 session per week for a total of 6 weeks with the option of 2 additional sessions.
Daily report of bedtime and wake time.
Baseline:
Polysomnography
Actigraphy
Questionnaires
Blood draw
Urine collection
2 weeks:
Questionnaires
Actigraphy download
Sleep log reconciliation
6 weeks:
Polysomnography
Actigraphy download
sleep log reconciliation
Questionnaires
Blood draw
Urine collection

Sleep Disturbances in Survivors of Critical Illness

- Therapy session administered by a clinical psychologist using web-based video conferencing software.
Therapy sessions will include:
Sleep restriction therapy
Stimulus control instructions
Sleep hygiene education

Cognitive Behavioral Therapy for Insomnia (CBT-I)

Therapy will be administered by a senior Johrei administrator at the University of Arizona or the patient's residence.
Therapy sessions will consist of 3 sessions per week lasting 30 minutes each.
Therapist will wash his hands and and pray for 1 minute while facing the subject at a distance.
Therapy will be administered without physical contact.
During therapy the administrator will sit adjacent to the patient and channel energy from his palm towards the patient.

Johrei therapy

University of Arizona Medical Center

Johrei Therapy and CBT-I in Facilitating Sleep in ICU Survivors

Comparative-effectiveness of Johrei Therapy and CBT-I in Facilitating Sleep in ICU Survivors

Objectively measures periods of quiescence that could be inferred to be sleep.

Used to record bedtimes, wake times, and naps and will then be reconciled with actigraphy downloads.

Measure of Alertness at different times during the day.

Measures response to stressful life experiences.

Measures circulating levels of cytokines and neurotransmitters through blood and urine collection.

There is no plan to share IPD information.

University of Arizona

The Johrei Institute

Participants will ingest 500ml of BioSteel Sports Drink 3 times during an exercise session.

Participants will orally ingest 500ml of Isoenergetic Control (0.18 calories/kg body weight) 2 times separated by 60 minutes.

Fatigue

BioSteel Sports Drink

Participants will ingest 500ml of Gatorade 3 times during an exercise session.

Isoenergetic Control

3M CTR - Rm 2235

BioSteel Supplementation and Performance

The Effect of BioSteel Sports Drink Supplementation on Muscular Fatigue, Cognitive Function, and Recovery Following Sprint Interval Exercise

Wingate test: Will be conducted using a cycle ergometer which electronically measures power (average, peak and decline). Resistance will be equal to 10% of subject body mass in kg.

Modified Stroop test- a measurement of attentional fatigue and executive function, will be scored based on error rate and mean response time (Kane & Kay, 1992).

Sitting medicine ball toss using a standard 4kg medicine ball. Where the ball first lands will be measured as the total distance (recorded in cm.)

Standing long jump will be conducted from a standing start with feet together. The distance from the jumping line to the individuals heels will recorded as the total distance (recorded in cm.)

Vertical jump will be conducted from a standing start. Without a pre-step individual will jump as a high as possible. Measurement is to the nearest cm.

Bench press repetitions of 150 lbs (including the barbell) will be performed at a rate of 25 repetitions per minute.

Trail Making Test Part B- a measurement of visual attention and speed of processing, will be scored on total time to completion (Sanchez-Cubillo et al., 2009).

Ratings of perceived exertion: Will be assessed after each sprint interval trial and at the conclusion of muscular endurance and power testing via a Borg Scale (Noble et al., 1983).

University of Western Ontario, Canada

Efficacy and Tolerance of B-Back® on the Burnout Syndrome

2 tablets/day after breakfast during 12 weeks

Dietary supplement : B-Back® (α-casozepine, taurine, eleutherococcus senticosus, Extramel)

B-Back® placebo (without active compounds)

Cinical Pharmacology Department - Université Victor Segalen Bordeaux 2

Evaluation of the Efficacy and Tolerance of B-Back® on the Burnout Syndrome

Evaluation of the Efficacy and Tolerance of B-Back® on the Burnout Syndrome. Double-blind, Randomized, Monocentric Trial With Two Parallel Groups (B-Back® Verum Versus B-Back® Placebo)

taurine/træthed

Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis

Johrei Therapy and CBT-I in Facilitating Sleep in ICU Survivors

BioSteel Supplementation and Performance

Evaluation of the Efficacy and Tolerance of B-Back® on the Burnout Syndrome

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