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tryptophan/betændelse
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Spirocyclic compounds as tryptophan hydroxylase inhibitors
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FIELD OF THE INVENTION
The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example,
Spirocyclic compounds as tryptophan hydroxylase inhibitors
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FIELD OF THE INVENTION
The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example,
Spirocyclic compounds as tryptophan hydroxylase inhibitors
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FIELD OF THE INVENTION
The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example,
Spirocyclic compounds as tryptophan hydroxylase inhibitors
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FIELD OF THE INVENTION
The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example,
Spirocyclic compounds as tryptophan hydroxylase inhibitors
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FIELD OF THE INVENTION
The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example,
High-affinity tryptophan transporter
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BACKGROUND OF THE INVENTION
This invention is generally in the field of tryptophan transporters, and more specifically is drawn to a novel tryptophan transport system.
Tryptophan occupies a unique position at the interface between the immune system and cellular metabolism. It is the only amino acid
Anti-inflammatory peptides, and uses thereof
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a 371 National Phase Entry of International Patent Application No. PCT/EP2016/067090 filed on Jul. 18, 2016 which claims benefit under 35 U.S.C. .sctn. 119(b) of EP Application No. 15177013.8 filed Jul. 16, 2015 and EP Application No.
Treating allergic reactions and inflammatory responses with tri-and dipeptides
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FIELD OF THE INVENTION
The present invention relates to peptides having anti-inflammatory properties. In particular, the present invention relates to peptides through actions on cells that modify the leukocyte recruitment and activation cascade and the actions of mediators released from inflammatory
Composition having a muscle-relaxant and anti-inflammatory activity
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This is a national stage application filed under 35 U.S.C. .sctn. 371 of international application PCT/IB2015/056268, filed under the authority of the Patent Cooperation Treaty on Aug. 18, 2015, published; which claims the benefit of Patent Application No. TO2014A000672, filed on Aug. 19, 2014. The
Therapeutic agent for inflammatory bowel disease and TNF-.alpha. production inhibitor
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TECHNICAL FIELD
The present invention relates to an agent for treating or preventing an inflammatory bowel disease, comprising a particular amino acid(s). The present invention also relates to an agent for inhibiting TNF production, comprising a particular amino acid(s).
BACKGROUND ART
An
Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof
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FIELD OF THE INVENTION
The present invention relates to novel polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The present invention also relates to compositions containing the novel polypeptides, and use of same to
Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof
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FIELD OF THE INVENTION
The present invention relates to novel polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The present invention also relates to compositions containing the novel polypeptides, and use of same to
Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof
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FIELD OF THE INVENTION
The present invention relates to novel polypeptides (linear and cyclic) that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The present invention also relates to compositions containing the novel polypeptides,
Composition and method for improving sleep duration and quality
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INTRODUCTION
Adequate sleep promotes health and the immune system. Sleep disorders and complaints can occur during childhood, adolescence or adult life [1, 2]. Insufficient sleep affects children's physical health as well as emotional, cognitive and social development. In the youth and adolescent
Composition and method for improving sleep duration and quality
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INTRODUCTION
Adequate sleep promotes health and the immune system. Sleep disorders and complaints can occur during childhood, adolescence or adult life [1, 2]. Insufficient sleep affects children's physical health as well as emotional, cognitive and social development. In the youth and adolescent
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