willow/blødning

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United States Pharmacopeia Safety Review of Willow Bark.

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Willow bark (Salix spp.) is an ingredient in some dietary supplements. No serious adverse effects were reported from trials of willow bark extracts delivering 120 - 240 mg salicin (the purported active constituent) daily for up to 8 weeks. All studies involved adults only; none involved

[Life threatening intestinal bleeding in a Bearded Collie associated with a food supplement for horses].

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In a Bearded Collie with acute weakness, hematemesis, melena, painful abdomen and pale mucous membranes a hematocrit of 13% and panhypoproteinemia were found. This combination of findings was the manifestation of severe gastrointestinal bleeding. Despite intensive laboratory and imaging

Herbal medication: potential for adverse interactions with analgesic drugs.

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The use of herbal supplements in the US has increased dramatically in recent years. These products are not regulated by the Food and Drug Administration (FDA) with the same scrutiny as conventional drugs. Patients who use herbal supplements often do so in conjunction with conventional drugs. This

The early clinical history of salicylates in rheumatology and pain.

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The first clinical reports on the treatment of fever and pain with salicylate-containing natural willow bark remedies were made by the English clergyman Edward Stone in 1763. The pharmacologically active principles were isolated from natural sources by Italian, German and French scientists between

Potential interactions between alternative therapies and warfarin.

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Potential and documented interactions between alternative therapy agents and warfarin are discussed. An estimated one third of adults in the United States use alternative therapies, including herbs. A major safety concern is potential interactions of alternative medicine products with prescription

History of drugs for thrombotic disease. Discovery, development, and directions for the future.

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The history of the antithrombotic agents--aspirin, heparin, warfarin, and the thrombolytics--is a rich and lively odyssey of serendipity, perseverance, vision, and conflict involving a number of striking personalities. The history of aspirin spans ages and continents from Hippocrates' analgesic for

Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics.

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Although initially described as an anti-tumor mediator, tumor necrosis factor-alpha (TNF) is generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis (RA), inflammatory bowel disease, ankylosing

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