Effect of Garlic on Inflammatory Mediators
Schlüsselwörter
Abstrakt
Beschreibung
To investigate the pharmacokinetics of one of the garlic oil macerate, Ajoene, the anti-inflammatory effect of garlic oil macerate on the pro-inflammatory transcription factor NF-kB, it's activating proteins, including IkB, IkB Kinases a and B (IKKa and IKKB) and the pro-inflammatory NF-kB-regulated proteins, c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), plasminogen activated protein-1 (PAI-1)and the effect of garlic oil macerate intake on platelet activation in normal subjects.
Termine
| Zuletzt überprüft: | 02/28/2007 |
| Zuerst eingereicht: | 01/09/2006 |
| Geschätzte Einschreibung eingereicht: | 01/09/2006 |
| Zuerst veröffentlicht: | 01/11/2006 |
| Letztes eingereichtes Update: | 03/18/2007 |
| Letztes Update veröffentlicht: | 03/19/2007 |
| Tatsächliches Startdatum der Studie: | 03/31/2006 |
| Voraussichtliches Abschlussdatum der Studie: | 02/28/2007 |
Zustand oder Krankheit
Intervention / Behandlung
Drug: Garlic Oil Macerate
Phase
Zulassungskriterien
| Altersberechtigt für das Studium | 18 Years Zu 18 Years |
| Studienberechtigte Geschlechter | All |
| Akzeptiert gesunde Freiwillige | Ja |
| Kriterien | Inclusion Criteria: - 18 years of age and older - Normal subjects with BMI <25, obese subjects with BMI >30 - Subjects who have consented to adhere to the diet, regular weekly visits, and blood draws. Exclusion Criteria: - Subjects on any antioxidant medication. - Patient on non-steroidal anti-inflammatory drug. - On any agent with antioxidant properties. - History of drug or alcohol abuse. - Any life threatening disease. - On any agent with significant antioxidant properties. - Taking garlic extracts in the diet regularly. |
Ergebnis
Primäre Ergebnismaße
1. 1. To examine the pharmacokinetics of the garlic oil macerate. [undefined]
Sekundäre Ergebnismaße
1. 2. To examine the effect of garlic oil macerate on inflammatory mechanisms at the cellular and molecular level. [undefined]
