[Anti-inflammatory and analgesic effects of saponins from D. zingiberensis C. H. Wright and diosgenin derivative on mice].
Schlüsselwörter
Abstrakt
OBJECTIVE
To determine the potential anti-inflammatory and analgesic activities of saponins from D. zingiberensis C. H. Wright and diosgenin derivative on xylene-induced acute ear edema in mice.
METHODS
3beta-2-acetoxy-benzoyl-diosgenin ester (ABDE) was synthesized by acylation of aspirin through two-step of reaction. The analgesic activities of ABDE and saponins were investigated through acetic acid-induced writhing response of the mice. The anti-inflammatory effects of saponins and ABDE were observed on the xylene-induced swelling ears of the mice.
RESULTS
The structure of ABDE was confirmed by 1H-NMR and ESI-MS. ABDE had significantly higher anti-inflammatory and analgesic activities than the comparison drug. The saponins demonstrated 7.92% and 14.51% anti-inflammatory activities at the dose of 126 mg/kg and 252 mg/kg, respectively, and 15.38% and 26.15% analgesic activities at the dose of 126 mg/kg and 252 mg/kg, respectively.
CONCLUSIONS
The saponins of D. zingiberensis C. H. Wright possess acute nonspecific anti-inflammatory and analgesic effects. The anti-inflammatory and analgesic effects of ABDE are equivalent to aspirin.
