[Drugs and diarrhea].

Drug induced diarrhea is a frequent adverse event. The pathophysiological mechanisms include intraluminal accumulation of osmotically active substances, increased secretion or impaired resorption of gastrointestinal fluids, stimulation of gastrointestinal motility, or inflammation of gastrointestinal mucosa. For many drugs, however, the causative mechanism is unknown. A careful drug history, including non-prescription drugs and additives that frequently cause diarrhea, is essential for the identification of potential causative substances. The clinical course of drug-induced diarrhea in many cases is mild and self-limited. In severe cases fluid-and electrolyte substitution, symptomatic and in certain cases specific therapy can be necessary. Symptomatic treatment primarily includes opioids and intraluminal adsorbents. In special cases octreotide or scopolamine can be used.