Zhongguo Zhongyao Zazhi 2005-Apr
[Experimental study on treatment of minimal change nephropathy with Lespedeza michx].
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Abstrakt
OBJECTIVE
To study the therapeutic effect of Lespedeza Michx in experimental rat model of minimal change nephropathy (MCN).
METHODS
The rat MCN model was reproduced by tail-intravenous injection of Adriamycin. The treatment effect of Lespedeza Michx was determined by the detection of urine protein collection for 24 hours, malondialdehyde (MDA), superoxide dismutase (SOD), ATCO, IL-8, TNF-alpha in serum, and renal histopathological changes were observed by microscope.
RESULTS
Lespedeza Michx could decrease the contents of urine proteinuria, MDA, IL-8, and TNF-alpha in serum, increase SOD level and improved the pathological change of glomeruli.
CONCLUSIONS
Lespedeza Michx was effective on MCN.
