Hypohidrosis related to the administration of topiramate to children.

OBJECTIVE

Topiramate (TPM) is an antiepileptic agent, first licensed in the United Kingdom in 1994, that is used in the treatment of patients with refractory seizure disorders. TPM is a monosaccharide d-fructose derivate, with sulfamate function, and so far, few adverse side effects have been reported.

METHODS

We describe three patients with epilepsy who were treated with TPM and developed hypohidrosis, heat and exercise intolerance, as well as fever. The sudomotor function was assessed after peripheral stimulation with pilocarpine iontophoresis.

RESULTS

Sweat response was reduced in all three patients. Signs and symptoms ceased after drug suppression.

CONCLUSIONS

This side effect associated with TPM, which has not been described previously, can be clinically significant during heat stress and exercise challenge.