Clinical and Experimental Pharmacology and Physiology 1990-May
Influence of neonatal hypothyroidism on adrenal tyrosine hydroxylase activation in the young rat.
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Abstrakt
1. Adrenal TH activation was elicited in young rats (aged 4, 6 and 14 days) by insulin hypoglycaemia. In the control rats, TH activation varied between 125 and 147% above basal values. 2. Neonatal hypothyroidism induced by PTU treatment impaired TH activation. Compensatory treatment with T3 to the PTU-treated young rats led to a return to control activation.