[Nonvolatile chemical constituents from Pogostemon cablin].

OBJECTIVE

To investigate the nonvolatile chemical constituents from the ethanol extract of the stems of Pogostemon cablin.

METHODS

The constituents were isolated and purified by repeated column chromatography on silica gel and Sephadex LH-20. Their structures were identified by physicochemical properties and spectroscopic analysis.

RESULTS

Twelve compounds were isolated and identified as tilianin (1), diosmetin-7-O-beta-D-glucopyranoside (2), 3"-O-methylcrenatoside (3), uracil (4), soya-cerebroside I and II (5), agastachoside (6), apigenin-7-O-(3", 6"-di-(E) -p-coumaroyl) -beta-D-galactopyranoside (7), 5-hydroxy-3, 3', 4', 7- tetramethoxy flavone (8), 4', 5-dihydroxy-3, 3', 7-trimethoxyflavone (9), acacetin (10), crenatoside (11), isocrenatoside (12).

CONCLUSIONS

Compounds 1, 2, 4-7, 10 were isolated from the genus Pogostemon for the first time.